Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene (Q24548619)

2

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R L Boyd

3

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J J Emmins

4

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J I Rood

Virulence studies on chromosomal alpha-toxin and theta-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of alpha-toxin in Clostridium perfringens-mediated gas gangrene

5

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language of work or name

English

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publication date

December 2001

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published in

Infection and Immunity

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volume

69

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page(s)

7904-10

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issue

12

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cites work

1 reference

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Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene

24 March 2017

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Virulence genes of Clostridium perfringens.

27 September 2017

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Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells

27 September 2017

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Phospholipase C and perfringolysin O from Clostridium perfringens upregulate endothelial cell-leukocyte adherence molecule 1 and intercellular leukocyte adherence molecule 1 expression and induce interleukin-8 synthesis in cultured human umbilical v

27 September 2017

1 reference

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Clostridium perfringens invasiveness is enhanced by effects of theta toxin upon PMNL structure and function: the roles of leukocytotoxicity and expression of CD11/CD18 adherence glycoprotein

27 September 2017

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Molecular analysis of transferable tetracycline resistance plasmids from Clostridium perfringens

27 September 2017

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An upstream regulatory sequence stimulates expression of the perfringolysin O gene of Clostridium perfringens

27 September 2017

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Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens

27 September 2017

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Electroporation-mediated transformation of lysostaphin-treated Clostridium perfringens

30 May 2018

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New pUC-derived cloning vectors with different selectable markers and DNA replication origins.

30 May 2018

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Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens

30 May 2018

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Construction and virulence testing of a collagenase mutant of Clostridium perfringens

28 November 2018

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Clostridium perfringens-Escherichia coli Shuttle Vectors That Carry Single Antibiotic Resistance Determinants

28 November 2018

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Gene cloning shows the alpha-toxin of Clostridium perfringens to contain both sphingomyelinase and lecithinase activities

28 November 2018

1 reference

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Lethal effects and cardiovascular effects of purified alpha- and theta-toxins from Clostridium perfringens

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11705975

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11705975

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clostridial gas gangrene. II. Phospholipase C-induced activation of platelet gpIIbIIIa mediates vascular occlusion and myonecrosis in Clostridium perfringens gas gangrene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11705975

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/IAI.69.12.7904-7910.2001

1 reference

830754

830754

1 reference

1 reference

1 reference