CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA (Q24550765)

2

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E M Suess

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J Meisenhelder

4

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N E Thompson

5

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K A Jones

Molecular and Cellular Biology

6

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language of work or name

English

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publication date

September 2000

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published in

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volume

20

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page(s)

6958-69

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issue

18

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cites work

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Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages

24 March 2017

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PITALRE, the catalytic subunit of TAK, is required for human immunodeficiency virus Tat transactivation in vivo

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DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

24 March 2017

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The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II

24 March 2017

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Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription

24 March 2017

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Structural basis of cyclin-dependent kinase activation by phosphorylation

24 March 2017

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Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex

24 March 2017

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Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor

24 March 2017

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

24 March 2017

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24 March 2017

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Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription

24 March 2017

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NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation

24 March 2017

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Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes

24 March 2017

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Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation

24 March 2017

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A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

24 March 2017

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P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

24 March 2017

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24 March 2017

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TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines

24 March 2017

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Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro

24 March 2017

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Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase

7 April 2017

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Reversible phosphorylation of the C-terminal domain of RNA polymerase II

7 April 2017

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Interactions between equine cyclin T1, Tat, and TAR are disrupted by a leucine-to-valine substitution found in human cyclin T1.

7 April 2017

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27 September 2017

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HIV-1 Tat: coping with negative elongation factors

27 September 2017

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Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription

27 September 2017

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Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication

27 September 2017

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Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism

27 September 2017

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Human and rodent transcription elongation factor P-TEFb: interactions with human immunodeficiency virus type 1 tat and carboxy-terminal domain substrate

27 September 2017

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Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation

27 September 2017

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Distinct roles for CTD Ser-2 and Ser-5 phosphorylation in the recruitment and allosteric activation of mammalian mRNA capping enzyme

27 September 2017

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Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase

27 September 2017

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Specific interaction of Tat with the human but not rodent P-TEFb complex mediates the species-specific Tat activation of HIV-1 transcription

27 September 2017

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Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b.

27 September 2017

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Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T

27 September 2017

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Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.

27 September 2017

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The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

27 September 2017

1 reference

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The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat.

27 September 2017

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Transfer of Tat and release of TAR RNA during the activation of the human immunodeficiency virus type-1 transcription elongation complex

27 September 2017

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Optimal Tat-mediated activation of the HIV-1 LTR promoter requires a full-length TAR RNA hairpin

27 September 2017

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A functional interaction between the carboxy-terminal domain of RNA polymerase II and pre-mRNA splicing

27 September 2017

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Purification of eukaryotic RNA polymerase II by immunoaffinity chromatography. Elution of active enzyme with protein stabilizing agents from a polyol-responsive monoclonal antibody.

27 September 2017

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The HIP1 initiator element plays a role in determining the in vitro requirement of the dihydrofolate reductase gene promoter for the C-terminal domain of RNA polymerase II.

27 September 2017

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27 September 2017

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Topological localization of the carboxyl-terminal domain of RNA polymerase II in the initiation complex

27 September 2017

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HIV-1 tat transcriptional activity is regulated by acetylation

27 September 2017

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HIV-1 Tat interacts with cyclin T1 to direct the P-TEFb CTD kinase complex to TAR RNA.

30 May 2018

1 reference

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Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation

30 May 2018

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Transcriptional pausing at +62 of the HIV-1 nascent RNA modulates formation of the TAR RNA structure

30 May 2018

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30 May 2018

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30 May 2018

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Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase.

30 May 2018

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Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity

30 May 2018

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12 December 2020

DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats

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12 December 2020

Immunoaffinity purification of RNA polymerase II and transcription factors using polyol-responsive monoclonal antibodies

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12 December 2020

Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation

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12 December 2020