A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube (Q24556567)

1

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Fausto Ulloa

2

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Stavroula V Tsoni

3

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Anita Mynett

Gli proteins and the control of spinal-cord patterning

4

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language of work or name

English

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publication date

1 March 2005

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published in

Genes & Development

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volume

19

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issue

5

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page(s)

626-41

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cites work

1 reference

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Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

24 March 2017

1 reference

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Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

24 March 2017

1 reference

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Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

24 March 2017

1 reference

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A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

24 March 2017

1 reference

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Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

24 March 2017

1 reference

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Efficient selection for high-expression transfectants with a novel eukaryotic vector

24 March 2017

1 reference

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Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities

24 March 2017

1 reference

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Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning

24 March 2017

1 reference

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Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

24 March 2017

1 reference

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Vertebrate neurogenesis is counteracted by Sox1-3 activity

24 March 2017

1 reference

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Gli1 can rescue the in vivo function of Gli2

24 March 2017

1 reference

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Hedgehog signaling in animal development: paradigms and principles

24 March 2017

1 reference

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Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification

24 March 2017

1 reference

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The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Morphogens, compartments, and pattern: lessons from drosophila?

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development

24 March 2017

1 reference

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Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

24 March 2017

1 reference

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A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

A series of normal stages in the development of the chick embryo

24 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=551582

7 April 2017

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Effective targeted gene 'knockdown' in zebrafish

28 November 2018

1 reference

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Neuronal specification in the spinal cord: inductive signals and transcriptional codes

7 April 2017

1 reference

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Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos

7 April 2017

1 reference

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A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

7 April 2017

1 reference

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The emergent design of the neural tube: prepattern, SHH morphogen and GLI code

7 April 2017

1 reference

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SOX2 functions to maintain neural progenitor identity

27 September 2017

1 reference

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27 September 2017

1 reference

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27 September 2017

1 reference

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Whole-genome analysis of dorsal-ventral patterning in the Drosophila embryo

27 September 2017

1 reference

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Dorsal gradient networks in the Drosophila embryo

27 September 2017

1 reference

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Morphogen gradient interpretation

27 September 2017

1 reference

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Specification of neuronal fates in the ventral neural tube

27 September 2017

1 reference

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27 September 2017

1 reference

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27 September 2017

1 reference

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Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube

27 September 2017

1 reference

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27 September 2017

1 reference

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27 September 2017

1 reference

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27 September 2017

1 reference

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One hundred years of positional information

27 September 2017

1 reference

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27 September 2017

1 reference

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27 September 2017

1 reference

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27 September 2017

1 reference

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30 May 2018

1 reference

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30 May 2018

1 reference

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30 May 2018

1 reference

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dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo

30 May 2018

1 reference

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30 May 2018

1 reference

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28 November 2018

1 reference

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28 November 2018

1 reference

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Neural crest development is regulated by the transcription factor Sox9.

28 November 2018

1 reference

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28 November 2018

1 reference

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28 November 2018

1 reference

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28 November 2018

1 reference

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Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis.

28 November 2018

1 reference

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28 November 2018

1 reference

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28 November 2018

1 reference

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A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

28 November 2018

1 reference

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NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos.

28 November 2018

1 reference

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28 November 2018

1 reference

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Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

28 November 2018

1 reference

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28 November 2018

1 reference

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1 reference

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Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate

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12 December 2020