The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes (Q24562884)

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English	The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes	scientific article

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16 October 2019

The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes (English)

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16 October 2019

G protein-coupled receptor

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Junichi Sadoshima

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16 October 2019

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S Izumo

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1 February 1996

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16 October 2019

The EMBO Journal

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16 October 2019

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16 October 2019

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16 October 2019

775-787

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16 October 2019

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts

1 reference

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Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

1 reference

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24 March 2017

Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains

1 reference

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1 reference

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Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype

1 reference

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

1 reference

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Proteins regulating Ras and its relatives

1 reference

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RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

1 reference

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24 March 2017

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1 reference

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24 March 2017

MAP kinase pathways in yeast: for mating and more

1 reference

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24 March 2017

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1 reference

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24 March 2017

Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

1 reference

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24 March 2017

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

7 April 2017

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

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7 April 2017

Signal transduction by lymphocyte antigen receptors

1 reference

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7 April 2017

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

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7 April 2017

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

1 reference

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7 April 2017

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1 reference

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7 April 2017

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

7 April 2017

Signal transduction via the MAP kinases: proceed at your own RSK.

1 reference

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27 September 2017

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

27 September 2017

Activators and effectors of ras p21 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

27 September 2017

Raf meets Ras: completing the framework of a signal transduction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

27 September 2017

Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

27 September 2017

Regulation of Ras-mediated signalling: more than one way to skin a cat.

1 reference

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27 September 2017

Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascade

1 reference

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Heterotrimeric G proteins: organizers of transmembrane signals

1 reference

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27 September 2017

Dimerization of cell surface receptors in signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

27 September 2017

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

27 September 2017

Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals

1 reference

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Cytokine signaling through nonreceptor protein tyrosine kinases

1 reference

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The when and how of Src regulation

1 reference

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Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts

1 reference

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27 September 2017

Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway

1 reference

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Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

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Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

27 September 2017

Function of Ras as a molecular switch in signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

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Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

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Solution structure of the SH3 domain of Src and identification of its ligand-binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

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Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

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p21 Ras as a governor of global gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450276

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A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

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Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts

1 reference

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Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

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Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1 reference

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Agonist-induced phosphorylation of the vascular type 1 angiotensin II receptor

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Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8631299

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Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts

1 reference

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inferred from PubMed ID database lookup

Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling

1 reference

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inferred from PubMed ID database lookup

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

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inferred from PubMed ID database lookup

Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway

1 reference

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inferred from PubMed ID database lookup

Identifiers

10.1002/J.1460-2075.1996.TB00413.X

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8631299%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8631299%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8631299%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

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