X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B (Q24562944)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7568220%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

title

X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B (English)

1 reference

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21 October 2019

main subject

hemophilia

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coagulation factor IX

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0 references

1

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21 October 2019

author name string

M Bauer

2

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21 October 2019

R Huber

3

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21 October 2019

P Lollar

4

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21 October 2019

W Bode

5

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21 October 2019

language of work or name

English

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publication date

1 October 1995

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Proceedings of the National Academy of Sciences of the United States of America

21 October 2019

published in

1 reference

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21 October 2019

volume

92

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21 October 2019

page(s)

9796-9800

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21 October 2019

issue

21

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Isolation and characterization of a cDNA coding for human factor IX

21 October 2019

cites work

1 reference

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24 March 2017

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24 March 2017

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24 March 2017

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24 March 2017

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The three‐dimensional structure of the first EGF‐like module of human factor IX: Comparison with EGF and TGF‐α

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

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Structure of the Ca(2+)-free Gla domain sheds light on membrane binding of blood coagulation proteins

27 September 2017

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Missense mutations and evolutionary conservation of amino acids: evidence that many of the amino acids in factor IX function as "spacer" elements

27 September 2017

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How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.

27 September 2017

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The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-tryp

27 September 2017

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Reactivity of bovine blood coagulation factor IXa beta, factor Xa beta, and factor XIa toward fluorogenic peptides containing the activation site sequences of bovine factor IX and factor X.

27 September 2017

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Inhibition of activated porcine factor IX by dansyl-glutamyl-glycyl-arginyl-chloromethylketone

27 September 2017

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Mutations in the catalytic domain of factor IX that are related to the subclass hemophilia Bm.

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Determinants of the factor IX mutational spectrum in haemophilia B: an analysis of missense mutations using a multi-domain molecular model of the activated protein

30 May 2018

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The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin

30 May 2018

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30 May 2018

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A monoclonal antibody to factor IX that inhibits the factor VIII:Ca potentiation of factor X activation

30 May 2018

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Expression and characterization of human factor IX and factor IX-factor X chimeras in mouse C127 cells

30 May 2018

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Structural requirements for Ca2+ binding to the gamma-carboxyglutamic acid and epidermal growth factor-like regions of factor IX. Studies using intact domains isolated from controlled proteolytic digests of bovine factor IX.

30 May 2018

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30 May 2018

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Human factor IX has a tetrasaccharide O-glycosidically linked to serine 61 through the fucose residue

30 May 2018

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The active site of factor IXa is located far above the membrane surface and its conformation is altered upon association with factor VIIIa. A fluorescence study

30 May 2018

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30 May 2018

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Factor IX Fukuoka. Substitution of ASN92 by His in the second epidermal growth factor-like domain results in defective interaction with factors VIIa/X.

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Direct sequencing of the activation peptide and the catalytic domain of the factor IX gene in six species

28 November 2018

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Intrinsic pathway activation of factor X and its activation peptide-deficient derivative, factor Xdes-143-191

28 November 2018

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12 December 2020

The role of phospholipid and factor VIIIa in the activation of bovine factor X

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12 December 2020

Stabilization of thrombin-activated porcine factor VIII:C by factor IXa phospholipid

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12 December 2020

Assembly of the intrinsic factor X activating complex--interactions between factor IXa, factor VIIIa and phospholipid

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12 December 2020

Mechanism of activation of bovine factor X (Stuart factor) by intrinsic and extrinsic pathways

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12 December 2020

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. The refined crystal structures of the bovine trypsinogen-pancreatic trypsin inhibitor complex and of its ternary complex with Ile-Val at 1.9 A resolution

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12 December 2020

Degradation of coagulation proteins by an enzyme from Malayan pit viper (Akistrodon rhodostoma) venom

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12 December 2020

A new trisaccharide sugar chain linked to a serine residue in bovine blood coagulation factors VII and IX

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12 December 2020

Effects of gamma-carboxyglutamic acid and epidermal growth factor-like modules of factor IX on factor X activation. Studies using proteolytic fragments of bovine factor IX

1 reference

12 December 2020

The role of the first growth factor domain of human factor IXa in binding to platelets and in factor X activation

1 reference

12 December 2020

Aminonaphthalenesulfonamides, a new class of modifiable fluorescent detecting groups and their use in substrates for serine protease enzymes

1 reference

12 December 2020

Construction, expression, and characterization of a chimera of factor IX and factor X. The role of the second epidermal growth factor domain and serine protease domain in factor Va binding

1 reference

12 December 2020

The binding of human factor IX to endothelial cells is mediated by residues 3-11

1 reference

12 December 2020

Restriction-site PCR: a direct method of unknown sequence retrieval adjacent to a known locus by using universal primers

1 reference

12 December 2020

Tyrosine 69 of the first epidermal growth factor-like domain of human factor IX is essential for clotting activity

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12 December 2020

Molecular biology of hemophilia B

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12 December 2020

Ca(2+)-dependent interactions between Gla and EGF domains in human coagulation factor IX

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12 December 2020

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12 December 2020

Mechanism-based isocoumarin inhibitors for blood coagulation serine proteases. Effect of the 7-substituent in 7-amino-4-chloro-3-(isothioureidoalkoxy)isocoumarins on inhibitory and anticoagulant potency

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12 December 2020

Structure of membrane-bound human factor Va

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12 December 2020

Membrane binding properties of the factor IX gamma-carboxyglutamic acid-rich domain prepared by chemical synthesis

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12 December 2020

Inhibition by heparin of the human blood coagulation intrinsic pathway factor X activator

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12 December 2020

A kinetic evaluation of activated bovine blood coagulation factor IX toward synthetic substrates

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12 December 2020

Identifiers

DOI

10.1073/PNAS.92.21.9796

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7568220%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7568220%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

1 reference