Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor (Q24563382)

3

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author name string

Alessandro Fraldi

2

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Todd E Adamson

4

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François Bonnet

5

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Van Trung Nguyen

6

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Stanley C Sedore

7

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Jason P Price

8

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David H Price

9

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Luigi Lania

10

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Olivier Bensaude

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

11

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language of work or name

English

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publication date

7 July 2004

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published in

The EMBO Journal

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volume

23

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issue

13

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page(s)

2608-19

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cites work

1 reference

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MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

24 March 2017

1 reference

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Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells

24 March 2017

1 reference

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Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors

24 March 2017

1 reference

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Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro

24 March 2017

1 reference

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Identification of multiple cyclin subunits of human P-TEFb

24 March 2017

1 reference

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Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription

24 March 2017

1 reference

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7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

24 March 2017

1 reference

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Structure, expression, and functional characterization of the mouse CLP-1 gene

24 March 2017

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The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

24 March 2017

1 reference

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A highly purified RNA polymerase II elongation control system

24 March 2017

1 reference

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DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation

24 March 2017

1 reference

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6S RNA regulates E. coli RNA polymerase activity

24 March 2017

1 reference

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NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation

24 March 2017

1 reference

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A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

24 March 2017

1 reference

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P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

24 March 2017

1 reference

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Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase

7 April 2017

1 reference

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U1 snRNA associates with TFIIH and regulates transcriptional initiation

7 April 2017

1 reference

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Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.

27 September 2017

1 reference

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CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo

27 September 2017

1 reference

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HIV-1 TAR RNA enhances the interaction between Tat and cyclin T1.

27 September 2017

1 reference

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Yeast three-hybrid system to detect and analyze RNA-protein interactions

27 September 2017

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Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

27 September 2017

1 reference

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Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.

27 September 2017

1 reference

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The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

27 September 2017

1 reference

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G protein mutations that alter the pheromone response in Saccharomyces cerevisiae

27 September 2017

1 reference

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PKR--a protein kinase regulated by double-stranded RNA.

27 September 2017

1 reference

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Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600275

RNA molecules stimulate prion protein conversion

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600275

Identification of a novel isoform of Cdk9.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600275

Distinct regions of cyclinT1 are required for binding to CDK9 and for recruitment to the HIV-1 Tat/TAR complex.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449783

28 November 2018

Identifiers

DOI

10.1038/SJ.EMBOJ.7600275

1 reference

4705428

4705428

1 reference

1 reference

1 reference