Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins (Q24564014)

1

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M Baldwin

2

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J Nguyen

3

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M Gasset

4

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A Serban

5

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D Groth

6

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I Mehlhorn

7

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Z Huang

8

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R J Fletterick

Proceedings of the National Academy of Sciences of the United States of America

9

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language of work or name

English

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publication date

1 December 1993

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published in

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volume

90

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page(s)

10962-6

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issue

23

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cites work

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Mice devoid of PrP are resistant to scrapie

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

7 April 2017

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Synthetic peptides corresponding to different mutated regions of the amyloid gene in familial Creutzfeldt-Jakob disease show enhanced in vitro formation of morphologically different amyloid fibrils

27 September 2017

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Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity

27 September 2017

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Primary structure elements responsible for the conformational switch in the envelope glycoprotein gp120 from human immunodeficiency virus type 1: LPCR is a motif governing folding

27 September 2017

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A kinetic model for amyloid formation in the prion diseases: importance of seeding

27 September 2017

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Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform

27 September 2017

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Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies

27 September 2017

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Purified prion proteins and scrapie infectivity copartition into liposomes

27 September 2017

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Separation and properties of cellular and scrapie prion proteins

27 September 2017

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A cellular gene encodes scrapie PrP 27-30 protein

27 September 2017

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Asparagine-linked glycosylation of the scrapie and cellular prion proteins

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Adenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

pH-dependent structural transitions of Alzheimer amyloid peptides

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Are prions misfolded molecular chaperones?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Molecular location of a species-specific epitope on the hamster scrapie agent protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Molecular biology of prion diseases

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Purification and properties of the cellular prion protein from Syrian hamster brain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Synthesis and trafficking of prion proteins in cultured cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Regional mapping of prion proteins in brain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Use of polylysine for adsorption of nuclei acids and enzymes to electron microscope specimen films

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Improvements in protein secondary structure prediction by an enhanced neural network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Molecular characteristics of prion rods purified from scrapie-infected hamster brains

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Identification of a gene which controls the incubation period of some strains of scrapie agent in mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Amyloid plaques in Creutzfeldt-Jakob disease stain with prion protein antibodies.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Predicted secondary structure and membrane topology of the scrapie prion protein

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

CNS amyloid proteins in neurodegenerative diseases.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Structural basis of latency in plasminogen activator inhibitor-1

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Neurotoxicity of a prion protein fragment.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

MacMatch: a tool for pattern-based protein secondary structure prediction.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Brain regional distribution of prion protein PrP27-30 in mice stereotaxically microinjected with different strains of scrapie.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Scrapie prions aggregate to form amyloid-like birefringent rods

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Purification and properties of the cellular and scrapie hamster prion proteins

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47901

Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein

28 November 2018

1 reference

12 December 2020

Beta-pleated sheet fibrils. A comparison of native amyloid with synthetic protein fibrils

1 reference

12 December 2020

A rapid sensitive silver stain for polypeptides in polyacrylamide gels

1 reference

12 December 2020

Calculation of protein conformation from circular dichroism

1 reference

12 December 2020

Secondary structure and dosage of soluble and membrane proteins by attenuated total reflection Fourier-transform infrared spectroscopy on hydrated films

1 reference

12 December 2020

Protein secondary structure of the isolated photosystem II reaction center and conformational changes studied by Fourier transform infrared spectroscopy

1 reference

12 December 2020

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.90.23.10962

1 reference

1786234

ADS bibcode

1993PNAS...9010962P

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1786234

1 reference

1 reference

1 reference