Rationale for interleukin-6 blockade in systemic lupus erythematosus (Q24564990)

systemic lupus erythematosus

Europe PubMed Central

title

Rationale for interleukin-6 blockade in systemic lupus erythematosus (English)

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main subject

interleukins

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1 reference

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E Tackey

1

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P E Lipsky

series ordinal

2

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G G Illei

series ordinal

3

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language of work or name

English

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publication date

2004

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published in

Lupus

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volume

13

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issue

5

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page(s)

339-43

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cites work

The paradigm of IL-6: from basic science to medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Anti-dsDNA antibody up-regulates interleukin 6, but not cyclo-oxygenase, gene expression in glomerular mesangial cells: a marker of immune-mediated renal damage?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Interleukin 6 plays a key role in the development of antigen-induced arthritis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Cytokine production (IL-6 and TNF alpha) in whole blood cell cultures of patients with systemic lupus erythematosus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Increased release of von Willebrand factor antigen from endothelial cells by anti-DNA autoantibodies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Role of interleukin-6 in the progression of mesangial proliferative glomerulonephritis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Interleukin-6 exacerbates glomerulonephritis in (NZB x NZW)F1 mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Interleukin 6 promotes murine lupus in NZB/NZW F1 mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Heterogeneity of B cell responsiveness to interleukin 4, interleukin 6 and low molecular weight B cell growth factor in discrete stages of B cell activation in patients with systemic lupus erythematosus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Exogenous IL-10 and IL-4 down-regulate IL-6 production by SLE-derived PBMC.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

IL-6 receptor blockage inhibits the onset of autoimmune kidney disease in NZB/W F1 mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Possible role of IL-6 in pathogenesis of immune complex-mediated glomerulonephritis in NZB/W F1 mice: induction of IgG class anti-DNA autoantibody production.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

In vitro regulation of B cell differentiation by interleukin-6 and soluble CD23 in systemic lupus erythematosus B cell subpopulations and antigen-induced normal B cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Age-dependent responsiveness to interleukin-6 in B lymphocytes from a systemic lupus erythematosus-prone (NZB × NZW)F1 hybrid

30 May 2018

1 reference

https://api.crossref.org/works/10.1191%2F0961203304LU1023OA

Macrophage depletion decreases IgG anti-DNA in cultures from (NZB · NZW)F1 spleen cells by eliminating the main source of IL-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1191%2F0961203304LU1023OA

Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1191%2F0961203304LU1023OA

Renal expression of IL-6 and TNFalpha genes in lupus nephritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1191%2F0961203304LU1023OA

Cytokine production, serum levels and disease activity in systemic lupus erythematosus

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

CD40 ligand-activated human monocytes amplify glomerular inflammatory responses through soluble and cell-to-cell contact-dependent mechanisms

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014821

Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha from normal human mononuclear cells involving in the lupus pathogenesis

28 November 2018

1 reference

12 December 2020

IL-6 is required for the development of Th1 cell-mediated murine colitis

1 reference

12 December 2020

Increased excretions of beta2-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm-Horsfall glycoprotein in urine of patients with active lupus nephritis

1 reference

12 December 2020

Impairment of CD8+ T suppressor cell function in patients with active systemic lupus erythematosus

1 reference

12 December 2020

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

1 reference

12 December 2020

Immunologic abnormality in NZB/W F1 mice. Thymus-independent expansion of B cells responding to interleukin-6

1 reference

12 December 2020

The prognostic significance of urinary interleukin 6 in IgA nephropathy

1 reference

12 December 2020

Age-associated increase in interleukin 6 in MRL/lpr mice

1 reference

12 December 2020

Distribution of interleukin-6 in normal and diseased human kidney

1 reference

12 December 2020

Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression

1 reference

12 December 2020

Induction of interleukin 6 synthesis in mouse glomeruli and cultured mesangial cells

1 reference

12 December 2020

Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells

1 reference

12 December 2020

Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal

1 reference

12 December 2020

Urinary levels of IL-6 in patients with active lupus nephritis

1 reference

12 December 2020

Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus

1 reference

12 December 2020

Cellular localization of inflammatory cytokines in human glomerulonephritis

1 reference

12 December 2020

Experimental study on intramuscular injection of eukaryotic expression vector pcDNA3- IL-6 on BXSB mice

1 reference

12 December 2020

Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-gamma-secreting cells in the peripheral blood

1 reference

12 December 2020

Upregulation of adhesion molecule expression on endothelial cells by anti-DNA autoantibodies in systemic lupus erythematosus

1 reference

12 December 2020

Anti-DNA autoantibodies stimulate the release of interleukin-1 and interleukin-6 from endothelial cells

1 reference

12 December 2020

Presence of tumor necrosis factor alpha and interleukin-6 in renal mesangial cells of lupus nephritis patients

1 reference

12 December 2020

Serum and urinary interleukin-6 in systemic lupus erythematosus

1 reference

12 December 2020

Autoreactive T cell clones from patients with systemic lupus erythematosus support polyclonal autoantibody production

1 reference

12 December 2020

10.1191/0961203304LU1023OA

Identifiers

DOI

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3315463

3315463

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