Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice (Q24595114)

1

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Frederick Bauzon

2

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Peng Ji

3

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Xiaoliang Xu

4

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Daqian Sun

5

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Joseph Locker

6

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Rani S Sellers

7

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Keiko Nakayama

8

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Keiich I Nakayama

9

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Liang Zhu

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

11

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language of work or name

English

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publication date

January 2010

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published in

Nature Genetics

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volume

42

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issue

1

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page(s)

83-8

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Effects of an Rb mutation in the mouse

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Skp2 suppresses p53-dependent apoptosis by inhibiting p300.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

A Skp2 autoinduction loop and restriction point control

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

F-box protein Skp2: a novel transcriptional target of E2F.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Cyclin E-CDK2 is a regulator of p27Kip1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

A dynamic switch in Rb+/- mediated neuroendocrine tumorigenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

E2F4 loss suppresses tumorigenesis in Rb mutant mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990528

Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19966802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19966802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NG.498

1 reference

Dimensions Publication ID

1048072755

0 references

1 reference

1 reference

PubMed publication ID

19966802

1 reference