The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator (Q24598801)

1

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Molly Johannessen

2

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Abdol R Hajipour

3

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Nicholas V Cozzi

4

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Meyer B Jackson

5

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Arnold E Ruoho

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors

6

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language of work or name

English

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publication date

13 February 2009

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published in

Science

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volume

323

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page(s)

934-7

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issue

5916

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cites work

1 reference

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Trace amines: identification of a family of mammalian G protein-coupled receptors

24 March 2017

1 reference

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Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

The mysterious trace amines: protean neuromodulators of synaptic transmission in mammalian brain

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

sigma Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Generation and phenotypic analysis of sigma receptor type I (σ1) knockout mice

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Enzymatic formation of psychotomimetic metabolites from normally occurring compounds

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Sigma receptor photolabeling and sigma receptor-mediated modulation of potassium channels in tumor cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8-C7 isomerase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

N, N-dimethyltryptamine: an endogenous hallucinogen.

27 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

27 September 2017

https://api.crossref.org/works/10.1126%2FSCIENCE.1166127

Behavioural changes induced by N,N-dimethyl-tryptamine in rodents

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Tryptamine, N,N-dimethyltryptamine, N,N-dimethyl-5-hydroxytryptamine and 5-methoxytryptamine in human blood and urine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Psychotomimetic N -Methylated Tryptamines: Formation in Brain in vivo and in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

(125I)iodoazidococaine, a photoaffinity label for the haloperidol-sensitive sigma receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Endogenous ligands for sigma opioid receptors in the brain ("sigmaphin"): evidence from binding assays

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

K+ channel modulation in rodent neurohypophysial nerve terminals by sigma receptors and not by dopamine receptors.

30 May 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1166127

Structural features important for sigma 1 receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1166127

Ontogeny of N,N-dimethyltryptamine and related indolealkylamine levels in neonatal rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1166127

Inhibition of potassium currents by the sigma receptor ligand (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine in sympathetic neurons of the mouse isolated hypogastric ganglion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1166127

Characterization of the cocaine binding site on the sigma-1 receptor

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

The sigma receptor as a ligand-regulated auxiliary potassium channel subunit

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

In vivo modulation of sigma receptor sites by calcitonin gene-related peptide in the mouse and rat hippocampal formation: radioligand binding and electrophysiological studies

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947205

Identification of regions of the sigma-1 receptor ligand binding site using a novel photoprobe

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19213917

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Correlation between neuroleptic binding to sigma(1) and sigma(2) receptors and acute dystonic reactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19213917

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1166127

1 reference

2217007

ADS bibcode

2009Sci...323..934F

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2217007

1 reference

1 reference

1 reference