Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments (Q24599152)

2

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M Novak

3

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I Grundke-Iqbal

4

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K Iqbal

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

5 June 2001

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published in

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volume

98

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page(s)

6923-8

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issue

12

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cites work

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Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

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Hyperphosphorylation of tau in PHF

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Structure of tau protein and assembly into paired helical filaments

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Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

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RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

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Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

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Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress

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Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein tau: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid

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Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament

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Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments

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Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition

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Alzheimer paired helical filaments: immunochemical identification of polypeptides

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Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease

27 September 2017

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Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

27 September 2017

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Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

27 September 2017

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27 September 2017

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Analysis of microtubule-associated protein tau glycation in paired helical filaments.

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30 May 2018

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Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3.

30 May 2018

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30 May 2018

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Observations on the brains of demented old people

30 May 2018

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Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

30 May 2018

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Defective brain microtubule assembly in Alzheimer's disease

30 May 2018

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

30 May 2018

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Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein.

30 May 2018

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Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

30 May 2018

1 reference

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The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34454

In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34454

Protein anatomy: C-tail region of human tau protein as a crucial structural element in Alzheimer's paired helical filament formation in vitro.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34454

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34454

Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34454

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34454

The organization of the microtubule associated protein tau in Alzheimer paired helical filaments.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34454

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34454

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34454

The microtubule-associated protein tau forms a triple-stranded left-hand helical polymer

28 November 2018

1 reference

12 December 2020

Polymerization of microtubule-associated protein tau under near-physiological conditions

1 reference

12 December 2020

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

1 reference

12 December 2020

Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal

1 reference

12 December 2020

Assay of proteins in the presence of interfering materials

1 reference

12 December 2020

Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease

1 reference

12 December 2020

Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations

1 reference

12 December 2020

Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease

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12 December 2020

Identifiers

DOI

10.1073/PNAS.121119298

1 reference

437178

ADS bibcode

2001PNAS...98.6923A

0 references

437178

1 reference

1 reference

1 reference