The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density (Q24602889)

2

0 references

B Cornett

3

0 references

K H Downing

4

0 references

E Nogales

Proceedings of the National Academy of Sciences of the United States of America

5

0 references

language of work or name

English

0 references

publication date

24 April 2001

0 references

published in

0 references

volume

98

0 references

issue

9

0 references

page(s)

5312-6

0 references

cites work

Structure of the alpha beta tubulin dimer by electron crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

High-resolution model of the microtubule

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Conformation of microtubule-bound paclitaxel determined by fluorescence spectroscopy and REDOR NMR.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

A common pharmacophore for cytotoxic natural products that stabilize microtubules

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Effect of 2'-OH acetylation on the bioactivity and conformation of 7-O-[N-(4'-fluoresceincarbonyl)-L-alanyl]taxol. A NMR-fluorescence microscopy study.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Crystal and molecular structure of paclitaxel (taxol).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Taxol binds to polymerized tubulin in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Synthesis and structure-activity relationships of new antitumor taxoids. Effects of cyclohexyl substitution at the C-3' and/or C-2 of taxotere (docetaxel).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Relationships between the structure of taxol analogs and their antimitotic activity

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Biologically active taxol analogs with deleted A-ring side chain substituents and variable C-2' configurations

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Direct photoaffinity labeling of tubulin with taxol

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33206

Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.051309398

Predominant labeling of beta- over alpha-tubulin from porcine brain by a photoactivatable taxoid derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.051309398

[3H](azidophenyl)ureido taxoid photolabels peptide amino acids 281-304 of alpha-tubulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.051309398

A fast flexible docking method using an incremental construction algorithm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.051309398

The oxetane ring in taxol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.051309398

Unexpectedly Facile Hydrolysis of the 2-Benzoate Group of Taxol and Syntheses of Analogs with Increased Activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.051309398

A Common Pharmacophore for Taxol and the Epothilones Based on the Biological Activity of a Taxane Molecule Lacking a C-13 Side Chain†

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.051309398

NMR and molecular modeling study of the conformations of taxol and of its side chain methylester in aqueous and non-aqueous solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.051309398

Characterization of the Taxol Binding Site on the Microtubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.051309398

Ab InitioConformational Study of the Phenylisoserine Side Chain of Paclitaxel

21 January 2018

1 reference

12 December 2020

Conformationally restricted paclitaxel analogues: macrocyclic mimics of the "hydrophobic collapse" conformation

1 reference

12 December 2020

Synthesis of a photoaffinity taxol analogue and its use in labeling tubulin

1 reference

12 December 2020

The effect of the aromatic rings of taxol on biological activity and solution conformation: synthesis and evaluation of saturated taxol and taxotere analogues

1 reference

12 December 2020

Crystal structure of 2-debenzoyl, 2-acetoxy paclitaxel (Taxol): conformation of the paclitaxel side-chain

1 reference

12 December 2020

NMR and molecular modeling study of the conformations of taxol 2'-acetate in chloroform and aqueous dimethyl sulfoxide solutions

1 reference

12 December 2020

Chemistry and Biology of Taxol

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.051309398

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1073/PNAS.051309398

1 reference

ADS bibcode

2001PNAS...98.5312S

0 references

1 reference

1 reference

PubMed publication ID

11309480

1 reference