Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat (Q24602893)

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English	Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat	scientific article

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scholarly article

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Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat (English)

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inferred from title

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inferred from title

Jens Damsgaard Mikkelsen

2

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author name string

Anne Marie D Axel

1

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Henrik H Hansen

3

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language of work or name

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publication date

June 2010

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Neuropsychopharmacology

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35

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7

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1464-76

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Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic-pharmacodynamic modelling approach

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7 April 2017

Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

7 April 2017

Weight loss produced by tesofensine in patients with Parkinson's or Alzheimer's disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

7 April 2017

The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats

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7 April 2017

Serotonergic drugs : effects on appetite expression and use for the treatment of obesity

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7 April 2017

High-fat diet induced adiposity in mice with targeted disruption of the dopamine-3 receptor gene

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

7 April 2017

Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity

1 reference

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27 September 2017

Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration

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27 September 2017

Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats

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27 September 2017

Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Monoamine receptors in the regulation of feeding behaviour and energy balance.

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27 September 2017

Central nervous system biogenic amine targets for control of appetite and energy expenditure

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27 September 2017

How can drug addiction help us understand obesity?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Modulation of eating by central catecholamine systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

A concise review on the therapeutics of obesity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Hypothalamic dopamine and serotonin in the regulation of food intake.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Norepinephrine and the control of food intake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Enantioselective behavioral effects of sibutramine metabolites

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27 September 2017

Increased responsiveness of ventromedial hypothalamic neurons to norepinephrine in obese versus lean mice: relation to the metabolic syndrome

1 reference

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27 September 2017

Dopaminergic agonists normalize elevated hypothalamic neuropeptide Y and corticotropin-releasing hormone, body weight gain, and hyperglycemia in ob/ob mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Comparison of changes in the extracellular concentration of noradrenaline in rat frontal cortex induced by sibutramine or d-amphetamine: modulation by alpha2-adrenoceptors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Thermogenic effects of sibutramine and its metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Noradrenergic alpha 1 and alpha 2 receptors: light microscopic autoradiographic localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Reversal of cirazoline- and phenylpropanolamine-induced anorexia by the alpha 1-receptor antagonist prazosin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

27 September 2017

Extracellular hypothalamic monoamines measured by in vivo microdialysis in a rat model of dietary fat-induced obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

30 May 2018

A comparison of the effects on central 5-HT function of sibutramine hydrochloride and other weight-modifying agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

30 May 2018

Bilateral hypothalamic dopamine infusion in male Zucker rat suppresses feeding due to reduced meal size

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

30 May 2018

Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

30 May 2018

Meal size and number: relationship to dopamine levels in the ventromedial hypothalamic nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

30 May 2018

Spontaneous feeding-related monoamine changes in rostromedial hypothalamus of the obese Zucker rat: a microdialysis study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

30 May 2018

Diurnal rhythms of paraventricular hypothalamic norepinephrine and food intake in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

30 May 2018

Haloperidol and apomorphine effects on ethanol reinforcement in free feeding rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

30 May 2018

Effects of food intake and body weight on a serotonergic turnover index in rat hypothalamus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

30 May 2018

Bidirectional dopaminergic modulation of excitatory synaptic transmission in orexin neurons.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Locomotion is the major determinant of sibutramine-induced increase in energy expenditure.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Selective binding of 2-[125I]iodo-nisoxetine to norepinephrine transporters in the brain

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Co-administration of dopamine D1 and D2 agonists additively decreases daily food intake, body weight and hypothalamic neuropeptide Y level in rats

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Pharmacological characterisation of the thermogenic effect of bupropion

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https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

7-OH-DPAT selectively reduces intake of both chow and high fat diets in different food intake regimens

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Dopamine and serotonin VMN release is related to feeding status in obese and lean Zucker rats.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Spontaneous feeding-related monoaminergic changes in the rostromedial hypothalamus revealed by microdialysis.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Plasticity of quantal size in ventral midbrain dopamine neurons: possible implications for the neurochemistry of feeding and reward.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Patterns of extracellular norepinephrine in the paraventricular hypothalamus: relationship to circadian rhythm and deprivation-induced eating behavior

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https://api.crossref.org/works/10.1038%2FNPP.2010.16

21 January 2018

Defense of differing body weight set points in diet-induced obese and resistant rats

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055463

28 November 2018

Specificity of alpha- and beta-adrenergic inhibition of water and food intake

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200509

12 December 2020

based on heuristic

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Effects on food and water intake of the alpha 1-adrenoceptor agonists amidephrine and SK&F-89748

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200509

12 December 2020

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Evidence that ACTH secretion is regulated by serotonin2A/2C (5-HT2A/2C) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200509

12 December 2020

based on heuristic

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The selective norepinephrine reuptake inhibitor, LY368975, reduces food consumption in animal models of feeding

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lateral hypothalamic serotonergic responsiveness to food intake in rat obesity as measured by microdialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sibutramine, a serotonin uptake inhibitor, increases dopamine concentrations in rat striatal and hypothalamic extracellular fluid

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of diet and obesity on brain alpha 1- and alpha 2-noradrenergic receptors in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic antidepressant drug regimes and food and water intake in rats

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https://pubmed.ncbi.nlm.nih.gov/20200509

12 December 2020

based on heuristic

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Identifiers

10.1038/NPP.2010.16

1 reference

Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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Springer Nature article ID

10.1038/npp.2010.16

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