A Randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder (Q24602988)

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English	A Randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder	scientific article

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5 February 2020

A Randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder (English)

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5 February 2020

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major depressive disorder

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Nancy Diazgranados

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5 February 2020

Carlos A Zarate Jr

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Carlos A Zarate

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5 February 2020

David A Luckenbaugh

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David A Luckenbaugh

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5 February 2020

Nancy E Brutsche

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Nancy Brutsche

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5 February 2020

Lobna A Ibrahim

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Lobna Ibrahim

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5 February 2020

Libby Jolkovsky

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Libby Jolkovsky

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5 February 2020

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W Joseph Herring

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5 February 2020

William Z Potter

7

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publication date

1 August 2012

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5 February 2020

Journal of Clinical Psychopharmacology

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5 February 2020

32

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5 February 2020

4

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5 February 2020

551-557

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5 February 2020

A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression

1 reference

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Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications

1 reference

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7 April 2017

A rating scale for depression

1 reference

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7 April 2017

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

1 reference

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7 April 2017

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

7 April 2017

Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice

1 reference

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7 April 2017

The assessment of anxiety states by rating

1 reference

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7 April 2017

Antidepressant effects of ketamine in depressed patients

1 reference

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A rating scale for mania: reliability, validity and sensitivity

1 reference

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7 April 2017

A New Depression Scale Designed to be Sensitive to Change

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

7 April 2017

The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

27 September 2017

Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist.

1 reference

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27 September 2017

The role of the tripartite glutamatergic synapse in the pathophysiology and therapeutics of mood disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

27 September 2017

An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

27 September 2017

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

27 September 2017

Rapid onset of antidepressant action: a new paradigm in the research and treatment of major depressive disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

27 September 2017

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

27 September 2017

Antidepressants and the risk of suicidal behaviors

1 reference

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27 September 2017

The definition and meaning of treatment-resistant depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

27 September 2017

Measurement of feelings using visual analogue scales.

1 reference

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A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

30 May 2018

Quantitative rating of depressive states

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

30 May 2018

Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

28 November 2018

Single-dose administration of MK-0657, an NR2B-selective NMDA antagonist, does not result in clinically meaningful improvement in motor function in patients with moderate Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438886

28 November 2018

Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors.

1 reference

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28 November 2018

Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides.

1 reference

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28 November 2018

In vitro and antinociceptive profile of HON0001, an orally active NMDA receptor NR2B subunit antagonist.

1 reference

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28 November 2018

The responsiveness of the Hamilton Depression Rating Scale

1 reference

https://pubmed.ncbi.nlm.nih.gov/22722512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of depression: the depression inventory

1 reference

https://pubmed.ncbi.nlm.nih.gov/22722512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Hamilton depression scale. Evaluation of objectivity using logistic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22722512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of dissociative states with the Clinician-Administered Dissociative States Scale (CADSS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22722512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simple options for improving signal detection in antidepressant clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/22722512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1097/JCP.0B013E31825D70D6

1 reference

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5 February 2020

1 reference

Europe PubMed Central

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5 February 2020

1 reference

Europe PubMed Central

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5 February 2020

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