A single polymorphism in HIV-1 subtype C SP1 is sufficient to confer natural resistance to the maturation inhibitor bevirimat (Q24606079)

5

object named as

Eric O Freed

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author name string

Wuxun Lu

1

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Karl Salzwedel

2

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Suvobrata Chakravarty

4

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Carl T Wild

6

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Feng Li

Antimicrobial Agents and Chemotherapy

7

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language of work or name

English

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publication date

July 2011

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published in

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volume

55

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issue

7

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page(s)

3324-9

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describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3122462/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection

1 reference

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Safety and pharmacokinetics of Bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers

7 April 2017

1 reference

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Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration

7 April 2017

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The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid

7 April 2017

1 reference

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Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat

7 April 2017

1 reference

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Phenotypic susceptibility to bevirimat in isolates from HIV-1-infected patients without prior exposure to bevirimat

27 September 2017

1 reference

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Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457)

27 September 2017

1 reference

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Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection

27 September 2017

1 reference

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Multiple-dose pharmacokinetics and safety of bevirimat, a novel inhibitor of HIV maturation, in healthy volunteers

27 September 2017

1 reference

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In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat).

27 September 2017

1 reference

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Infectious molecular clone of a recently transmitted pediatric human immunodeficiency virus clade C isolate from Africa: evidence of intraclade recombination

27 September 2017

1 reference

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Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation

27 September 2017

1 reference

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Protease inhibition in African subtypes of HIV-1.

27 September 2017

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PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing

27 September 2017

1 reference

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Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gag.

27 September 2017

1 reference

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Construction and analysis of an infectious human Immunodeficiency virus type 1 subtype C molecular clone

27 September 2017

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A putative alpha-helical structure which overlaps the capsid-p2 boundary in the human immunodeficiency virus type 1 Gag precursor is crucial for viral particle assembly

27 September 2017

1 reference

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Susceptibility of human immunodeficiency virus type 1 to the maturation inhibitor bevirimat is modulated by baseline polymorphisms in Gag spacer peptide 1

27 September 2017

1 reference

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High prevalence of natural polymorphisms in Gag (CA-SP1) associated with reduced response to Bevirimat, an HIV-1 maturation inhibitor

30 May 2018

1 reference

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Determinants of activity of the HIV-1 maturation inhibitor PA-457.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122462

28 November 2018

Identifiers

DOI

10.1128/AAC.01435-10

1 reference

1005618

1005618

1 reference

1 reference

1 reference