Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway (Q24607012)

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Jiaping Gao

2

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Qing Yang

3

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Zhidan Wu

4

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Jesper Gromada

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

13 July 2010

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published in

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volume

107

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issue

28

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page(s)

12553-8

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cites work

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

7 April 2017

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AMPK and PPARdelta agonists are exercise mimetics

7 April 2017

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

7 April 2017

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BetaKlotho is required for metabolic activity of fibroblast growth factor 21

7 April 2017

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FGF-21 as a novel metabolic regulator

7 April 2017

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

7 April 2017

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Role of AMP-activated protein kinase in mechanism of metformin action

7 April 2017

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

7 April 2017

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

7 April 2017

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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

7 April 2017

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

7 April 2017

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Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation

7 April 2017

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

7 April 2017

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

7 April 2017

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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

7 April 2017

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

7 April 2017

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PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis

7 April 2017

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Fibroblast growth factor 21 corrects obesity in mice

27 September 2017

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Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways

27 September 2017

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Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

27 September 2017

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The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

27 September 2017

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Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

27 September 2017

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The role of AMP-activated protein kinase in mitochondrial biogenesis

27 September 2017

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Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice

27 September 2017

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Calorie restriction, SIRT1 and metabolism: understanding longevity

27 September 2017

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The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

27 September 2017

1 reference

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FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho

27 September 2017

1 reference

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Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906565

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906565

The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906565

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906565

Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906565

28 November 2018

Identifiers

DOI

10.1073/PNAS.1006962107

1 reference

ADS bibcode

2010PNAS..10712553C

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1 reference

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PubMed publication ID

20616029

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