Alanine scanning of a putative receptor binding surface of insulin-like growth factor-I (Q24608585)

7

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author name string

Lisbeth Gauguin

1

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Carlie Delaine

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Clair L Alvino

3

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Kerrie A McNeil

4

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John C Wallace

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

25 July 2008

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published in

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volume

283

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issue

30

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page(s)

20821-9

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cites work

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The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site

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Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site

30 May 2018

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Insulin-like growth factor (IGF)-II binding to IGF-binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II.

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A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity

30 May 2018

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Production and characterization of recombinant insulin-like growth factor-I (IGF-I) and potent analogues of IGF-I, with Gly or Arg substituted for Glu 3, following their expression in Escherichia coli as fusion proteins

30 May 2018

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Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development

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Model for the complex between the insulin-like growth factor I and its receptor: towards designing antagonists for the IGF-1 receptor.

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Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding

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Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies

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How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

21 January 2018

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A Novel Binding Site for the Human Insulin-like Growth Factor-II (IGF-II)/Mannose 6-Phosphate Receptor on IGF-II

21 January 2018

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An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors

21 January 2018

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Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

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Characterization of a second ligand binding site of the insulin receptor

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Alanine scanning mutagenesis of insulin

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Insulin-like growth factor I and its binding proteins: a study of the binding interface using B-domain analogues

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Structural domains of the insulin receptor and IGF receptor required for dimerisation and ligand binding

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A model for insulin binding to the insulin receptor

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The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor.

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18 Systematic mutational analyses of protein-protein interfaces

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Alanine-scanning mutagenesis of a C-terminal ligand binding domain of the insulin receptor alpha subunit

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