Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent (Q24613185)

1

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J Chen

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G Kuron

3

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V Hunt

4

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J Huff

5

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C Hoffman

6

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J Rothrock

7

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M Lopez

8

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H Joshua

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E Harris

10

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A Patchett

11

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R Monaghan

12

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S Currie

13

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E Stapley

14

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G Albers-Schonberg

15

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O Hensens

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J Hirshfield

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J Liesch

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J Springer

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language of work or name

English

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publication date

July 1980

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Crossref

full work available at URL

16 September 2022

https://europepmc.org/articles/pmc349746?pdf=render

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1073/pnas.77.7.3957?email=unpaywall_01@example.com

published in

Proceedings of the National Academy of Sciences of the United States of America

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volume

77

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page(s)

3957-61

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issue

7

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19 March 2024

https://api.unpaywall.org/v2/10.1073/pnas.77.7.3957?email=unpaywall_01@example.com

access restriction status

open access

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inferred from online access status

cites work

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium

1 reference

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Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum

7 April 2017

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The determination of enzyme inhibitor constants

7 April 2017

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Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

7 April 2017

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Therapeutic effects of ML-236B in primary hypercholesterolemia

27 September 2017

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Regulation of HMG-CoA reductase

27 September 2017

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Purification of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver

27 September 2017

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Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase

27 September 2017

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Cholesterol metabolism in man

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Dietary and Serum Lipids in the Multifactorial Etiology of Atherosclerosis

27 September 2017

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Concentration of lipoproteins containing apolipoprotein B in human peripheral lymph

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Hypolipidemic effects in monkeys of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

27 September 2017

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Kinetic Analysis of the Reaction Catalyzed by Rat-Liver 3-Hydroxy-3-methylglutaryl-coenzyme-A Reductase Using Two Specific Inhibitors

27 September 2017

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3-Hydroxy-3-methylglutaryl coenzyme A reductase from rat liver. Its purification, properties, and immunochemical studies

27 September 2017

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Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylgutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B

30 May 2018

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Monacolin K, a new hypocholesterolemic agent produced by a Monascus species.

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Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study

19 June 2018

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12 December 2020

Purification and characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase from chicken liver

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12 December 2020

Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

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12 December 2020

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

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12 December 2020

Inhibitory effects on lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase

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12 December 2020

Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium

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Effects of ML-236B on cholesterol metabolism in mice and rats: lack of hypocholesterolemic activity in normal animals

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A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity

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Monacolin K, a new hypocholesterolemic agent produced by a Monascus species.

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.32.852

Identifiers

DOI

10.1073/PNAS.77.7.3957

1 reference

593582

ADS bibcode

1980PNAS...77.3957A

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593582

1 reference

1 reference

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