Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide (Q24614147)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552008%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552008%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

0 references

1 reference

ChEBI release 2020-05-28

3

1 reference

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31 January 2020

author name string

A Lopez-Girona

1

1 reference

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31 January 2020

D Mendy

2

1 reference

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31 January 2020

K Miller

4

1 reference

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31 January 2020

A K Gandhi

5

1 reference

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31 January 2020

J Kang

6

1 reference

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31 January 2020

S Karasawa

7

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31 January 2020

G Carmel

8

1 reference

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31 January 2020

P Jackson

9

1 reference

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31 January 2020

M Abbasian

10

1 reference

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31 January 2020

A Mahmoudi

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552008%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

B Cathers

12

1 reference

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31 January 2020

E Rychak

13

1 reference

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31 January 2020

S Gaidarova

14

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31 January 2020

R Chen

15

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31 January 2020

P H Schafer

16

1 reference

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31 January 2020

H Handa

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552008%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

T O Daniel

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552008%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

J F Evans

19

1 reference

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31 January 2020

R Chopra

20

1 reference

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31 January 2020

language of work or name

English

0 references

publication date

3 May 2012

1 reference

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31 January 2020

1 reference

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31 January 2020

volume

26

1 reference

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31 January 2020

issue

11

1 reference

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31 January 2020

page(s)

2326-2335

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describes a project that uses

31 January 2020

DF15

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DF15R

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cites work

Identification of a primary target of thalidomide teratogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Thalidomide is an inhibitor of angiogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Cereblon is expressed in the retina and binds to voltage-gated chloride channels

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

High-density miniaturized thermal shift assays as a general strategy for drug discovery

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

A review of the history, properties, and use of the immunomodulatory compound lenalidomide.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Pomalidomide therapy for myeloma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Functional modulation of AMP-activated protein kinase by cereblon

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Lenalidomide in multiple myeloma: an evidence-based review of its role in therapy.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Recent advances of IMiDs in cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Primary function analysis of human mental retardation related gene CRBN.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Properties of thalidomide and its analogues: implications for anticancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

IMiD immunomodulatory compounds block C/EBP{beta} translation through eIF4E down-regulation resulting in inhibition of MM.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

mRNA distribution of the thalidomide binding protein cereblon in adult mouse brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Pharmacokinetics of lenalidomide in subjects with various degrees of renal impairment and in subjects on hemodialysis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

The evolution of thalidomide and its IMiD derivatives as anticancer agents

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496085

Embryotoxicity and teratogenicity of thalidomide in rats

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22552008

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

TERATOGENIC EFFECTS OF THALIDOMIDE IN RABBITS, RATS, HAMSTERS, AND MICE

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22552008

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/LEU.2012.119

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552008%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

31 January 2020

1008299299

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552008%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552008%20AND%20SRC:MED&resulttype=core&format=json