Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell (Q24619138)

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

Europe PubMed Central

title

Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell (English)

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author name string

George G Holz

series ordinal

1

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language of work or name

English

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publication date

January 2004

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published in

Diabetes

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volume

53

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issue

1

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page(s)

5-13

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cites work

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Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

7 April 2017

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

7 April 2017

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A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events

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Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

7 April 2017

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Triggering and amplifying pathways of regulation of insulin secretion by glucose

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Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells

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cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

7 April 2017

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Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

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A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

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cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells

7 April 2017

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Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

7 April 2017

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Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I

7 April 2017

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Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

7 April 2017

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Glucagon-Like Peptide-1 Synthetic Analogs: New Therapeutic Agents for Use in the Treatment of Diabetes Mellitus

7 April 2017

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cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension

27 September 2017

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Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger

27 September 2017

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Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac

27 September 2017

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SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells

27 September 2017

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Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

27 September 2017

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Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis

27 September 2017

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Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic beta cells

27 September 2017

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Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor

27 September 2017

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Involvement of the ryanodine-sensitive Ca2+ store in GLP-1-induced Ca2+ oscillations in insulin-secreting HIT cells

27 September 2017

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A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

27 September 2017

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Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism

27 September 2017

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Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

27 September 2017

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The ryanodine receptor calcium channel of beta-cells: molecular regulation and physiological significance

27 September 2017

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New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.

27 September 2017

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27 September 2017

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Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

27 September 2017

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Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

27 September 2017

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Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT).

27 September 2017

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Mobilization of Ca2+ stores in individual pancreatic beta-cells permeabilized or not with digitonin or alpha-toxin.

27 September 2017

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The glucagon-like peptides

27 September 2017

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Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential

27 September 2017

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Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.

27 September 2017

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Glucagon-like peptide 1 elevates cytosolic calcium in pancreatic beta-cells independently of protein kinase A.

27 September 2017

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Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells

27 September 2017

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In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation.

27 September 2017

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Anchoring of protein kinase A facilitates hormone-mediated insulin secretion

27 September 2017

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Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

27 September 2017

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Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept

27 September 2017

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Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization

27 September 2017

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Evidence that Rap1 carboxylmethylation is involved in regulated insulin secretion

27 September 2017

1 reference

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Ca2+-induced Ca2+ release from the endoplasmic reticulum amplifies the Ca2+ signal mediated by activation of voltage-gated L-type Ca2+ channels in pancreatic beta-cells

27 September 2017

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cAMP-independent decrease of ATP-sensitive K+ channel activity by GLP-1 in rat pancreatic beta-cells.

30 May 2018

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Glucagon-like peptides

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Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.

30 May 2018

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Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).

30 May 2018

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Glucose-stimulated insulin secretion is not dependent on activation of protein kinase A.

30 May 2018

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Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na+]i associated with insulin secretion in pancreatic beta-cells

30 May 2018

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The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas

28 November 2018

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Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).

28 November 2018

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Insulin secretory deficiency and glucose intolerance in Rab3A null mice

28 November 2018

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Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion.

28 November 2018

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cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets

28 November 2018

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Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis

28 November 2018

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Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose

28 November 2018

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Fast and cAMP-sensitive mode of Ca(2+)-dependent exocytosis in pancreatic beta-cells

28 November 2018

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Are 5-hydroxytryptamine-preloaded beta-cells an appropriate physiologic model system for establishing that insulin stimulates insulin secretion?

28 November 2018

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Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria.

28 November 2018

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Beta-adrenergic-induced cytosolic redistribution of Rap1 in rat parotid acini: role in secretion

28 November 2018

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cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets

28 November 2018

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12 December 2020

Glucagon-like peptide-1 modulates Ca2+ current but not K+ATP current in intact mouse pancreatic B-cells

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12 December 2020

Crosstalk between the cAMP and inositol trisphosphate-signalling pathways in pancreatic beta-cells

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12 December 2020

Pseudosubstrate inhibition of cyclic AMP-dependent protein kinase in intact pancreatic islets: effects on cyclic AMP-dependent and glucose-dependent insulin secretion

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12 December 2020

Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells

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12 December 2020

Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors

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12 December 2020

GLP-I(7-36) amide augments Ba2+ current through L-type Ca2+ channel of rat pancreatic beta-cell in a cAMP-dependent manner

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12 December 2020

Effects of 5-hydroxytryptamine on rubidium ion fluxes and insulin release in cultured pancreatic islets

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12 December 2020

Glucagon-Like Peptide 1(7-36) Amide Stimulates Exocytosis in Human Pancreatic -Cells by Both Proximal and Distal Regulatory Steps in Stimulus-Secretion Coupling

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12 December 2020

Relative contribution of Ca2+-dependent and Ca2+-independent mechanisms to the regulation of insulin secretion by glucose

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12 December 2020

Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism

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12 December 2020

Identifiers

DOI

10.2337/DIABETES.53.1.5

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1 reference

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PubMed publication ID

14693691

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