Structural insight into KCNQ (Kv7) channel assembly and channelopathy (Q24619681)

1

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Kimberly A Clark

2

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James M Holton

3

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Daniel L Minor

SWISS-MODEL: An automated protein homology-modeling server

4

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language of work or name

English

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publication date

1 March 2007

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published in

Neuron

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volume

53

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issue

5

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page(s)

663-75

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cites work

1 reference

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A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly

7 April 2017

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The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry

7 April 2017

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Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

7 April 2017

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Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity

7 April 2017

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Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors

7 April 2017

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KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness

7 April 2017

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KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel

7 April 2017

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Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

7 April 2017

1 reference

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Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

7 April 2017

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Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs

7 April 2017

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Tetrameric coiled coil domain of Sendai virus phosphoprotein

7 April 2017

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Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels

7 April 2017

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High-resolution protein design with backbone freedom

7 April 2017

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Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

7 April 2017

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A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants

7 April 2017

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The CCP4 suite: programs for protein crystallography

7 April 2017

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Likelihood-enhanced fast rotation functions

7 April 2017

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Automated protein model building combined with iterative structure refinement

7 April 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

7 April 2017

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7 April 2017

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Trafficking of the Ca2+-activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper

7 April 2017

1 reference

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Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency

7 April 2017

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Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

7 April 2017

1 reference

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KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents

7 April 2017

1 reference

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Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy

7 April 2017

1 reference

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Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels

7 April 2017

1 reference

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Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy

7 April 2017

1 reference

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K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

7 April 2017

1 reference

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Spectroscopic Determination of Tryptophan and Tyrosine in Proteins*

7 April 2017

1 reference

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Coiled coils direct assembly of a cold-activated TRP channel

7 April 2017

1 reference

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The KCNQ1 potassium channel: from gene to physiological function

27 September 2017

1 reference

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Pathways modulating neural KCNQ/M (Kv7) potassium channels

27 September 2017

1 reference

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Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome

27 September 2017

1 reference

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The design of coiled-coil structures and assemblies

27 September 2017

1 reference

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The structure of alpha-helical coiled coils

27 September 2017

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27 September 2017

The Birth of a Channel

1 reference

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M-channels: neurological diseases, neuromodulation, and drug development.

27 September 2017

1 reference

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KCNQ1 mutations in patients with a family history of lethal cardiac arrhythmias and sudden death

27 September 2017

1 reference

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Selective heteromeric assembly of cyclic nucleotide-gated channels

27 September 2017

1 reference

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Leucine/isoleucine zipper coordination of ion channel macromolecular signaling complexes in the heart. Roles in inherited arrhythmias

27 September 2017

1 reference

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C-terminal domains implicated in the functional surface expression of potassium channels

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011230

Potassium channel ontogeny

27 September 2017

1 reference

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A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome

27 September 2017

1 reference

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Neuronal KCNQ potassium channels: physiology and role in disease.

27 September 2017

1 reference

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Characterization and subcellular localization of KCNQ1 with a heterozygous mutation in the C terminus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011230

A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011230

Potassium channels: some assembly required

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011230

Repacking protein cores with backbone freedom: structure prediction for coiled coils

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011230

Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011230

Determination of the helix and beta form of proteins in aqueous solution by circular dichroism.

30 May 2018

1 reference

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Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel

30 May 2018

1 reference

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Conformational transition between four and five-stranded phenylalanine zippers determined by a local packing interaction.

30 May 2018

1 reference

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Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.

28 November 2018

1 reference

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A structural requirement for processing the cardiac K+ channel KCNQ1.

28 November 2018

1 reference

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C-terminal interaction of KCNQ2 and KCNQ3 K+ channels

28 November 2018

1 reference

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Molecular replacement by evolutionary search.

28 November 2018

1 reference

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Genomic organization of the KCNQ1 K+ channel gene and identification of C-terminal mutations in the long-QT syndrome.

28 November 2018

1 reference

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Genomic organization and mutational analysis of KVLQT1, a gene responsible for familial long QT syndrome

28 November 2018

1 reference

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A founder mutation of the potassium channel KCNQ1 in long QT syndrome: implications for estimation of disease prevalence and molecular diagnostics

28 November 2018

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12 December 2020

Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing

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12 December 2020

[Mutational analysis of LQT genes in individuals with drug induced QT interval prolongation]

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Molecular recognition and assembly sequences involved in the subfamily-specific assembly of voltage-gated K+ channel subunit proteins

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12 December 2020

Sedimentation equilibrium as thermodynamic tool

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12 December 2020

The packing of α-helices: simple coiled-coils

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Crossref

https://api.crossref.org/works/10.1016%2FJ.NEURON.2007.02.010

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.NEURON.2007.02.010

1 reference

1 reference

1 reference

PubMed publication ID

17329207

1 reference