AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome (Q24623703)

Harry L Malech

15

0 references

Francis Deng

Francis Deng

3

0 references

Joseph Lopez

Joseph Lopez

2

0 references

Philip M Murphy

16

Philip M Murphy

0 references

Sandra Anaya-O'Brien

10

Sandra Anaya-O'Brien

0 references

author name string

Qian Liu

4

0 references

Teresa Ojode

5

0 references

Haoqian Chen

6

0 references

Jean Ulrick

7

0 references

Nana Kwatemaa

8

0 references

Corin Kelly

9

0 references

Mary Garofalo

11

0 references

Martha Marquesen

12

0 references

Dianne Hilligoss

13

0 references

Rosamma DeCastro

Journal of Cellular and Molecular Medicine

14

0 references

language of work or name

English

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publication date

October 2011

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published in

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volume

15

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issue

10

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page(s)

2071-81

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cites work

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WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4

7 April 2017

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Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization

7 April 2017

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Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

7 April 2017

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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

7 April 2017

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Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling

7 April 2017

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WHIM syndrome: congenital immune deficiency disease

27 September 2017

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Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia

27 September 2017

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Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndrome

27 September 2017

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Fluorescent CXCL12AF647 as a novel probe for nonradioactive CXCL12/CXCR4 cellular interaction studies

27 September 2017

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Distinct mechanisms of agonist-induced endocytosis for human chemokine receptors CCR5 and CXCR4

27 September 2017

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Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease

27 September 2017

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Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias

27 September 2017

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Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes.

27 September 2017

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WHIM syndrome, an autosomal dominant disorder: clinical, hematological, and molecular studies

27 September 2017

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Myelokathexis, a congenital disorder of severe neutropenia characterized by accelerated apoptosis and defective expression of bcl-x in neutrophil precursors.

27 September 2017

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A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection

27 September 2017

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Clinical features of myelokathexis and treatment with hematopoietic cytokines: a case report of two patients and review of the literature

27 September 2017

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A new familial immunodeficiency disorder characterized by severe neutropenia, a defective marrow release mechanism, and hypogammaglobulinemia

27 September 2017

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Clinical and biologic effects of granulocyte colony stimulating factor in the treatment of myelokathexis

27 September 2017

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Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome

27 September 2017

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Phase III prospective randomized double-blind placebo-controlled trial of plerixafor plus granulocyte colony-stimulating factor compared with placebo plus granulocyte colony-stimulating factor for autologous stem-cell mobilization and transplantatio

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21 January 2018

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WHIM syndrome and oral squamous cell carcinoma.

21 January 2018

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WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12

21 January 2018

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Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma

21 January 2018

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Myelokathexis treated with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF)

28 November 2018

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Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21070597

12 December 2020

inferred from PubMed ID database lookup

The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21070597

12 December 2020

inferred from PubMed ID database lookup

Chemokines and cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21070597

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1111/J.1582-4934.2010.01210.X

0 references

Fatcat ID

release_r6kz66j35zepdelpoibzj4k2ce

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/r6kz66j35zepdelpoibzj4k2ce

24 November 2022