Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei (Q24627940)

GeneDB

Nuclear Dbf2-related kinase

6 February 2019

1 reference

6 February 2019

Jiangtao Ma

1

0 references

Corinna Benz

2

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Raffaella Grimaldi

3

0 references

Christopher Stockdale

4

0 references

Paul Wyatt

5

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Julie Frearson

6

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Tansy C Hammarton

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

14 May 2010

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published in

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volume

285

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issue

20

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page(s)

15356-68

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cites work

Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1

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MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation

7 April 2017

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

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Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

7 April 2017

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Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening

7 April 2017

1 reference

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Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation

7 April 2017

1 reference

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Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein

7 April 2017

1 reference

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Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein

7 April 2017

1 reference

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The Aurora Kinase in Trypanosoma brucei plays distinctive roles in metaphase-anaphase transition and cytokinetic initiation

7 April 2017

1 reference

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The chromosomal passenger complex and a mitotic kinesin interact with the Tousled-like kinase in trypanosomes to regulate mitosis and cytokinesis

7 April 2017

1 reference

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The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor

7 April 2017

1 reference

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Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex

7 April 2017

1 reference

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Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

7 April 2017

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Identification of a novel chromosomal passenger complex and its unique localization during cytokinesis in Trypanosoma brucei

7 April 2017

1 reference

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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

7 April 2017

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Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma

7 April 2017

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Elucidation of a universal size-control mechanism in Drosophila and mammals

7 April 2017

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A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

7 April 2017

1 reference

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The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness

7 April 2017

1 reference

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Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis

27 September 2017

1 reference

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The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1.

27 September 2017

1 reference

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The RACK1 signal anchor protein from Trypanosoma brucei associates with eukaryotic elongation factor 1A: a role for translational control in cytokinesis

27 September 2017

1 reference

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27 September 2017

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In vivo regulation of Yorkie phosphorylation and localization.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Cytokinesis in trypanosomatids

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Trypanosoma brucei Polo-like kinase is essential for basal body duplication, kDNA segregation and cytokinesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

27 September 2017

1 reference

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Highly efficient stable transformation of bloodstream forms of Trypanosoma brucei.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Cell cycle regulation in Trypanosoma brucei

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

NDR kinases regulate essential cell processes from yeast to humans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

The RACK1 homologue from Trypanosoma brucei is required for the onset and progression of cytokinesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Protein kinases as drug targets in trypanosomes and Leishmania

27 September 2017

1 reference

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Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Initiation of cytokinesis is controlled through multiple modes of regulation of the Sid2p-Mob1p kinase complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Kinomics-structural biology and chemogenomics of kinase inhibitors and targets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Endocytosis of a glycosylphosphatidylinositol-anchored protein via clathrin-coated vesicles, sorting by default in endosomes, and exocytosis via RAB11-positive carriers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Development of RNA interference revertants in Trypanosoma brucei cell lines generated with a double stranded RNA expression construct driven by two opposing promoters

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

A non-radioactive method for the assay of many serine/threonine-specific protein kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

The tricornered gene, which is required for the integrity of epidermal cell extensions, encodes the Drosophila nuclear DBF2-related kinase.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Ndr protein kinase is regulated by phosphorylation on two conserved sequence motifs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Timing of nuclear and kinetoplast DNA replication and early morphological events in the cell cycle of Trypanosoma brucei

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

The F-box protein CFB2 is required for cytokinesis of bloodstream-form Trypanosoma brucei

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Centrosome-associated NDR kinase regulates centrosome duplication

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Stage-specific differences in cell cycle control in Trypanosoma brucei revealed by RNA interference of a mitotic cyclin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865264

Mob2p interacts with the protein kinase Orb6p to promote coordination of cell polarity with cell cycle progression.

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074591

Dbf2 is essential for cytokinesis and correct mitotic spindle formation in Candida albicans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074591

Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074591

The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074591

MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074591

Mutual regulation of cyclin-dependent kinase and the mitotic exit network

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074591

Hydroxyurea-induced synchronisation of bloodstream stage Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074591

Isolation of Trypanosoma brucei CYC2 and CYC3 cyclin genes by rescue of a yeast G(1) cyclin mutant. Functional characterization of CYC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074591

A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074591

A protein kinase specifically associated with proliferative forms of Trypanosoma brucei is functionally related to a yeast kinase involved in the co-ordination of cell shape and division

21 January 2018

1 reference

12 December 2020

Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei

1 reference

12 December 2020

The human tumour suppressor LATS1 is activated by human MOB1 at the membrane

1 reference

12 December 2020

Double-stranded RNA interference in Trypanosoma brucei using head-to-head promoters

1 reference

12 December 2020