ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models (Q24628845)

ORCID Public Data File 2021

author name string

Paige E Cramer

1

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John R Cirrito

2

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Daniel W Wesson

3

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C Y Daniel Lee

4

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J Colleen Karlo

5

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Adriana E Zinn

6

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Brad T Casali

7

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Jessica L Restivo

8

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Whitney D Goebel

9

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Michael J James

10

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Kurt R Brunden

11

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Gary E Landreth

Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

13

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language of work or name

English

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publication date

23 March 2012

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published in

Science

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volume

335

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page(s)

1503-6

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issue

6075

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cites work

1 reference

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ApoE promotes the proteolytic degradation of Abeta

7 April 2017

1 reference

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7 April 2017

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A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

7 April 2017

1 reference

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Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

7 April 2017

1 reference

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

7 April 2017

1 reference

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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

7 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217697

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

22 April 2017

2 references

https://api.crossref.org/works/10.1126/SCIENCE.1217697

22 April 2017

https://api.crossref.org/works/10.1126%2FSCIENCE.1217697

Analyzing real-time PCR data by the comparative C(T) method

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217697

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651582

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651582

Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model

7 April 2017

1 reference

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Nuclear receptors as therapeutic targets for Alzheimer's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651582

Alternative macrophage activation and metabolism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651582

Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice

27 September 2017

1 reference

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ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice

27 September 2017

1 reference

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A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.

27 September 2017

1 reference

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Retinoid X receptors: common heterodimerization partners with distinct functions

27 September 2017

1 reference

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Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model

27 September 2017

1 reference

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Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

27 September 2017

1 reference

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Bexarotene: a clinical review

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651582

Gamma rhythms and beta rhythms have different synchronization properties.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651582

Loss of olfactory function in dementing disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651582

APOE is a major susceptibility gene for Alzheimer's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651582

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

27 September 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217697

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217697

CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217697

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651582

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651582

Developmental differences in place-learning performance between C57BL/6 and DBA/2 mice parallel the ontogeny of hippocampal protein kinase C.

28 November 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217697

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1217697

1 reference

397916

397916

1 reference

1 reference

1 reference