A role for DRAK2 in the germinal center reaction and the antibody response (Q24630648)

5

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author name string

Zhenming Xu

2

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Hong Zan

3

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Craig M Walsh

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

4

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language of work or name

English

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publication date

August 2008

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published in

Autoimmunity

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volume

41

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issue

5

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page(s)

341-52

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cites work

1 reference

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7 April 2017

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DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis

7 April 2017

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Class switching and Myc translocation: how does DNA break?

7 April 2017

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A mathematical model for the germinal center morphology and affinity maturation

7 April 2017

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Bcl-XL and Bcl-2 repress a common pathway of cell death

7 April 2017

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A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger

7 April 2017

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7 April 2017

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Germinal-center organization and cellular dynamics

7 April 2017

1 reference

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DNA replication to aid somatic hypermutation

27 September 2017

1 reference

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Helper T cell-regulated B cell immunity

27 September 2017

1 reference

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High affinity germinal center B cells are actively selected into the plasma cell compartment.

27 September 2017

1 reference

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DNA repair in antibody somatic hypermutation

27 September 2017

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Nuclear localization of the serine/threonine kinase DRAK2 is involved in UV-induced apoptosis

27 September 2017

1 reference

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DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation

27 September 2017

1 reference

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A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity

27 September 2017

1 reference

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Follicular dendritic cells produce IL-15 that enhances germinal center B cell proliferation in membrane-bound form

27 September 2017

1 reference

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Textbook germinal centers?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

The germinal center response

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

Apoptosis in the development and maintenance of the immune system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

Death-receptor contribution to the germinal-center reaction.

27 September 2017

1 reference

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The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game.

27 September 2017

1 reference

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FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

CD40 ligand and appropriate cytokines induce switching to IgG, IgA, and IgE and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal IgM+IgD+ B cell line.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

The germinal center: a crucible for lymphocyte selection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

Life and death in germinal centers (redux).

27 September 2017

1 reference

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Germinal centres in T-cell-dependent antibody responses

27 September 2017

1 reference

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Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes

27 September 2017

1 reference

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Modelling two possible mechanisms for the regulation of the germinal center dynamics.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

Germinal center development

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

Germinal centre B cells: antigen specificity and changes in heavy chain class expression.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140869

Transgenic drak2 overexpression in mice leads to increased T cell apoptosis and compromised memory T cell development

30 May 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

Anti-viral effector T cell responses and trafficking are not dependent upon DRAK2 signaling following viral infection of the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

DRAK2 regulates memory T cell responses following murine coronavirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

Human germinal center T cells are unique Th cells with high propensity for apoptosis induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

Peanut lectin binding properties of germinal centres of mouse lymphoid tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

The humoral immune response to Haemophilus influenzae type b: a mathematical model based on T-zone and germinal center B-cell dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

Accumulation of somatic hypermutation and antigen-driven selection in rapidly cycling surface Ig+ germinal center (GC) B cells which occupy GC at a high frequency during the primary anti-hapten response in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

Imaging of germinal center selection events during affinity maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

B Cell Receptor Engagement and T Cell Contact Induce bcl-6 Somatic Hypermutation in Human B Cells: Identity with Ig Hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930802170633

Follicular dendritic cells in vitro modulate the expression of Fas and Bcl-2 on germinal center B cells

21 January 2018

1 reference

12 December 2020

Fas-mediated apoptosis eliminates B cells that acquire self-reactivity during the germinal center response to NP

1 reference

12 December 2020

The type of seeder cells determines the efficiency of germinal center reactions

1 reference

12 December 2020

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene

1 reference

12 December 2020

Follicular dendritic cell regulation of CXCR4-mediated germinal center CD4 T cell migration

1 reference

12 December 2020

Cutting edge: back to "one-way" germinal centers

1 reference

12 December 2020

Role of follicular dendritic cells in the apoptosis of germinal center B cells

1 reference

12 December 2020