Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis (Q24631958)

1

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Rongfeng Li

2

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Ryan M Phelan

3

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Michael F Freeman

4

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Kristos A Moshos

5

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Evan P Lloyd

6

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Craig A Townsend

Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis

7

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language of work or name

English

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publication date

19 September 2011

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published in

ChemBioChem

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volume

12

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issue

14

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page(s)

2159-65

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cites work

1 reference

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Crystal structure of carbapenam synthetase (CarA)

7 April 2017

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Crystal structure of carbapenem synthase (CarC)

7 April 2017

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7 April 2017

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Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis

7 April 2017

1 reference

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The Biosynthetic Gene Cluster for the β-Lactam Carbapenem Thienamycin in Streptomyces cattleya

7 April 2017

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Carbapenems, a new class of beta-lactam antibiotics. Discovery and development of imipenem/cilastatin

7 April 2017

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7 April 2017

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Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics

27 September 2017

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A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis.

27 September 2017

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A catalytic asymmetric route to carbapenems

27 September 2017

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A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase

27 September 2017

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Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity

27 September 2017

1 reference

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Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase

27 September 2017

1 reference

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gem-disubstituent effect: theoretical basis and synthetic applications

27 September 2017

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Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus.

27 September 2017

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27 September 2017

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Stereochemical Studies of EnzymicC-Methylations

27 September 2017

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Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya

27 September 2017

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Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase

30 May 2018

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Acetyl-CoA and propionyl-CoA carboxylation by Mycobacterium phlei. Partial purification and some properties of the enzyme

30 May 2018

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Current Status of Oral Carbapenem Development

30 May 2018

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Stereochemistry of methylation in thienamycin biosynthesis: example of a methyl transfer from methionine with retention of configuration

21 January 2018

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Stereochemical analysis of the methyl transfer catalyzed by cobalamin-dependent methionine synthase from Escherichia coli B

21 January 2018

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Carboxymethylproline synthase from Pectobacterium carotorova: a multifaceted member of the crotonase superfamily

21 January 2018

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Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora

21 January 2018

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Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline

21 January 2018

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Synthesis of (3S,5R)-carbapenam-3-carboxylic acid and its role in carbapenem biosynthesis and the stereoinversion problem

21 January 2018

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Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).

21 January 2018

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Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.

21 January 2018

1 reference

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Thioester Hydrolysis and CC Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily

21 January 2018

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Nocardicin A, a new monocyclic beta-lactam antibiotic. I. Discovery, isolation and characterization

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21913298

12 December 2020

inferred from PubMed ID database lookup

Screening for beta-lactam antibiotics in nature

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21913298

12 December 2020

inferred from PubMed ID database lookup

Biosynthesis of the beta-lactam antibiotic, thienamycin, by Streptomyces cattleya

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21913298

12 December 2020

inferred from PubMed ID database lookup

Selective hydride-mediated conjugate reduction of .alpha.,.beta.-unsaturated carbonyl compounds using [(Ph3P)CuH]6

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100366

7 January 2021