Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody-drug conjugate in development for the treatment of HER2-positive cancer (Q24632855)

2

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Bei Wang

3

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Dan Lu

4

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Ian E Krop

5

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Charles L Vogel

6

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Howard A Burris Iii

7

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Patricia M LoRusso

8

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Joo-Hee Yi

9

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Ola Saad

10

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Barbara Tong

11

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Yu-Waye Chu

12

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Scott Holden

13

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Amita Joshi

Cancer Chemotherapy and Pharmacology

14

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language of work or name

English

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publication date

May 2012

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published in

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volume

69

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issue

5

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page(s)

1229-40

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cites work

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

7 April 2017

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Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer

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Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy

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Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer

27 September 2017

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Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer

27 September 2017

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Antibody-maytansinoid conjugates designed to bypass multidrug resistance

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Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based review

27 September 2017

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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate

27 September 2017

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Semisynthetic maytansine analogues for the targeted treatment of cancer

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Arming antibodies: prospects and challenges for immunoconjugates

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27 September 2017

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Recent developments in the maytansinoid antitumor agents

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Immunoconjugates containing novel maytansinoids: promising anticancer drugs

27 September 2017

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Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.

27 September 2017

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Crossref

https://api.crossref.org/works/10.1007%2FS00280-011-1817-3

Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism.

21 January 2018

1 reference

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Clinical implications of pathophysiological and demographic covariates on the population pharmacokinetics of trastuzumab emtansine, a HER2-targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer

28 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22271209

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antimitotic Activity of the Potent Tumor Inhibitor Maytansine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22271209

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00280-011-1817-3

1 reference

Dimensions Publication ID

1031527271

0 references

1 reference

1 reference

PubMed publication ID

22271209

1 reference