Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3 (Q24633878)

1

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Megan Rausch

2

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Donghui Wang

3

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Jimmy Blair

4

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Byron Hann

5

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Kevan M Shokat

6

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Mark M Moasser

The protein kinase complement of the human genome

7

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language of work or name

English

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publication date

25 January 2007

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published in

Nature

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volume

445

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page(s)

437-41

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issue

7126

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cites work

1 reference

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

7 April 2017

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Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

7 April 2017

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

7 April 2017

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Redox redux: revisiting PTPs and the control of cell signaling

7 April 2017

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Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor

27 September 2017

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Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') is independent of EGFR expression level

27 September 2017

1 reference

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Preclinical studies with Erlotinib (Tarceva).

27 September 2017

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A novel pyridopyrimidine inhibitor of abl kinase is a picomolar inhibitor of Bcr-abl-driven K562 cells and is effective against STI571-resistant Bcr-abl mutants.

27 September 2017

1 reference

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c-erbB-3: a nuclear protein in mammary epithelial cells.

27 September 2017

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ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression

27 September 2017

1 reference

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6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity

27 September 2017

1 reference

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ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

27 September 2017

1 reference

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Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

27 September 2017

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Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies

27 September 2017

1 reference

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Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

30 May 2018

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Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia

30 May 2018

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Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE05474

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE05474

Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE05474

Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025857

Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025857

The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025857

Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025857

28 November 2018

Identifiers

DOI

10.1038/NATURE05474

1 reference

Dimensions Publication ID

753033

1008085582

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753033

1 reference

1 reference

1 reference