Narrative review: the role of leptin in human physiology: emerging clinical applications (Q24634811)

Christos Socrates Mantzoros

Europe PubMed Central

title

Narrative review: the role of leptin in human physiology: emerging clinical applications (English)

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main subject

physiology

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author

4

object named as

Christos S Mantzoros

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Theodoros Kelesidis

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ORCID Public Data File 2021

author name string

Theodore Kelesidis

1

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Iosif Kelesidis

2

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Sharon Chou

Annals of Internal Medicine

3

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language of work or name

English

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publication date

19 January 2010

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published in

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volume

152

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issue

2

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page(s)

93-100

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cites work

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Leptin does not mediate short-term fasting-induced changes in growth hormone pulsatility but increases IGF-I in leptin deficiency states

27 September 2017

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Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy

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27 September 2017

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27 September 2017

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Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

27 September 2017

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Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin,

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress

27 September 2017

1 reference

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Leptin increases uncoupling protein expression and energy expenditure

27 September 2017

1 reference

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Receptor-mediated regional sympathetic nerve activation by leptin.

27 September 2017

1 reference

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Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Human leptin levels are pulsatile and inversely related to pituitary-adrenal function.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty

27 September 2017

1 reference

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Sexual dimorphism in plasma leptin concentration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Effects of gender, body composition, and menopause on plasma concentrations of leptin.

27 September 2017

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Clinical review 77: evaluation of secondary amenorrhea

27 September 2017

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Abnormal splicing of the leptin receptor in diabetic mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Effect of fasting on serum leptin in normal human subjects.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Whither recombinant human leptin treatment for HIV-associated lipoatrophy and the metabolic syndrome?

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

American College of Sports Medicine position stand. The female athlete triad.

28 November 2018

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Epidemiology and course of anorexia nervosa in the community.

28 November 2018

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Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans.

28 November 2018

1 reference

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Long-term efficacy of leptin replacement in patients with generalized lipodystrophy

28 November 2018

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Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy

28 November 2018

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The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients

28 November 2018

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Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with r

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Human immunodeficiency virus type 1-related lipoatrophy and lipohypertrophy are associated with serum concentrations of leptin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Leptin-replacement therapy for lipodystrophy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Partial leptin deficiency and human adiposity.

28 November 2018

1 reference

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Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Leptin in relation to resumption of menses in women with anorexia nervosa.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Expression of leptin receptor isoforms in rat brain microvessels.

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

A leptin missense mutation associated with hypogonadism and morbid obesity.

28 November 2018

1 reference

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Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829242

Long-term leptin-replacement therapy for lipoatrophic diabetes

28 November 2018

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12 December 2020

Role of leptin in fat regulation

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Leptin levels, beta-cell function, and insulin sensitivity in families with congenital and acquired generalized lipoatropic diabetes

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12 December 2020

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

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12 December 2020

Decreased serum leptin in bulimia nervosa

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12 December 2020