Complement in age-related macular degeneration: a focus on function (Q24635874)

Additional evidence to support the role of a common variant near the complement factor I gene in susceptibility to age-related macular degeneration

Europe PubMed Central

title

Complement in age-related macular degeneration: a focus on function (English)

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1 reference

D T Bradley

1

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P F Zipfel

series ordinal

2

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A E Hughes

series ordinal

3

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language of work or name

English

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publication date

June 2011

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published in

Eye

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volume

25

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page(s)

683-93

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issue

6

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cites work

1 reference

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Variation near complement factor I is associated with risk of advanced AMD

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Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome

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Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

7 April 2017

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CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD

7 April 2017

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Susceptibility genes for age-related maculopathy on chromosome 10q26

7 April 2017

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A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

7 April 2017

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Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19

7 April 2017

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Complement factor H polymorphism in age-related macular degeneration

7 April 2017

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Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and Pathogens

7 April 2017

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Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

7 April 2017

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An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

7 April 2017

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Production of biologically active recombinant human factor H in Physcomitrella

7 April 2017

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Complement component 5a (C5a)

7 April 2017

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Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study

7 April 2017

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Systemic complement activation in age-related macular degeneration

7 April 2017

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A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration

7 April 2017

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Complement factor H variant increases the risk of age-related macular degeneration

7 April 2017

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An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

7 April 2017

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Complement. First of two parts

7 April 2017

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Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3

7 April 2017

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7 April 2017

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Complement factor H polymorphism and age-related macular degeneration

7 April 2017

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Complement factor B polymorphism 32W protects against age-related macular degeneration

7 April 2017

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Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.

27 September 2017

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Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration

27 September 2017

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Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

27 September 2017

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The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration

27 September 2017

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Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome

27 September 2017

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The complement component 5 gene and age-related macular degeneration

27 September 2017

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The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited

27 September 2017

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Antiangiogenic approaches to age-related macular degeneration today

27 September 2017

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Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome

27 September 2017

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Complement regulators and inhibitory proteins

27 September 2017

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Complement and immune defense: from innate immunity to human diseases

27 September 2017

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The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity

27 September 2017

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27 September 2017

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Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

27 September 2017

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27 September 2017

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27 September 2017

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Prospective study of incident age-related macular degeneration in relation to vigorous physical activity during a 7-year follow-up

27 September 2017

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Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking

27 September 2017

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The tick-over theory revisited: formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

27 September 2017

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27 September 2017

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Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins

27 September 2017

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Complement C3 variant and the risk of age-related macular degeneration

27 September 2017

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The clearance of apoptotic cells by complement

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration

27 September 2017

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27 September 2017

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27 September 2017

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The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q.

27 September 2017

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Activation of the complement system generates antibacterial peptides

27 September 2017

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27 September 2017

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Structure and function of complement C5 convertase enzymes

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27 September 2017

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Different regulation of factor H and FHL-1/reconectin by inflammatory mediators and expression of the two proteins in rheumatoid arthritis (RA).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178140

Regulation of the complement membrane attack pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178140

Evolution of the vertebrate genome as reflected in paralogous chromosomal regions in man and the house mouse

27 September 2017

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Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178140

Inhibition of the lytic action of cell-bound terminal complement components by human high density lipoproteins and apoproteins

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178140

Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178140

The SERPING1 gene and age-related macular degeneration

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178140

Localization of complement 1 inhibitor (C1INH/SERPING1) in human eyes with age-related macular degeneration

30 May 2018

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Support for the involvement of complement factor I in age-related macular degeneration

30 May 2018

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Smoking and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study.

21 January 2018

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Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study.

21 January 2018

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Postprandial increase of complement component 3 in normolipidemic patients with coronary artery disease: effects of expanded-dose simvastatin

21 January 2018

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https://api.crossref.org/works/10.1038%2FEYE.2011.37

Complement factor h autoantibodies and age-related macular degeneration.

21 January 2018

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https://api.crossref.org/works/10.1038%2FEYE.2011.37

Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration

21 January 2018

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https://api.crossref.org/works/10.1038%2FEYE.2011.37

Influence of donor C3 allotype on late renal-transplantation outcome.

21 January 2018

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Evidence for association between multiple complement pathway genes and AMD.

21 January 2018

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21 January 2018

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12 December 2020

Alpha 2-macroglobulin enhances prothrombin activation and thrombin potential by inhibiting the anticoagulant protein C/protein S system in cord and adult plasma

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12 December 2020

Hemolytic efficiencies of genetic variants of human C3

1 reference

12 December 2020

Genetic variability in complement activation modulates the systemic inflammatory response syndrome in children

1 reference

12 December 2020

Increased complement factor H with decreased factor B determined by proteomic differential displays as a biomarker of tai chi chuan exercise

1 reference

12 December 2020

Visual field deficits in early age-related macular degeneration

1 reference

12 December 2020

Activation of the classical pathway of complement by tobacco glycoprotein (TGP)

1 reference

12 December 2020

The Relationship of Dietary Lipid Intake and Age-Related Macular Degeneration in a Case-Control Study

1 reference

12 December 2020

Identifiers

DOI

10.1038/EYE.2011.37

1 reference

Dimensions Publication ID

807498

1038301048

0 references

807498

1 reference

1 reference

1 reference