Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor (Q24635953)

19 October 2023

Vladimir Yarov-Yarovoy

2

Vladimir

Yarov-Yarovoy

1 reference

19 October 2023

Roy Kahn

3

Roy

Kahn

1 reference

19 October 2023

Dalia Gordon

4

Dalia

Gordon

1 reference

19 October 2023

Michael Gurevitz

5

Michael

Gurevitz

1 reference

19 October 2023

Todd Scheuer

6

Todd

Scheuer

1 reference

19 October 2023

William A Catterall

7

William A

Catterall

1 reference

Proceedings of the National Academy of Sciences of the United States of America

19 October 2023

language of work or name

English

0 references

publication date

13 September 2011

0 references

published in

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volume

108

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issue

37

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page(s)

15426-31

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cites work

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Crystal structure and mechanism of a calcium-gated potassium channel

7 April 2017

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Crystal structure of toxin II from the scorpion Androctonus australis Hector refined at 1.3 A resolution

7 April 2017

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7 April 2017

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

7 April 2017

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Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations

7 April 2017

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From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

7 April 2017

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Multiple sequence alignment with Clustal X

7 April 2017

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Protein structure prediction using Rosetta

7 April 2017

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Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

7 April 2017

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Targeting voltage sensors in sodium channels with spider toxins.

27 September 2017

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Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins

27 September 2017

1 reference

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Deconstructing voltage sensor function and pharmacology in sodium channels

27 September 2017

1 reference

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Voltage-gated ion channels and gating modifier toxins.

27 September 2017

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Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.

27 September 2017

1 reference

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Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels

27 September 2017

1 reference

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Subtype specificity of scorpion beta-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3.

27 September 2017

1 reference

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Multipass membrane protein structure prediction using Rosetta

27 September 2017

1 reference

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Molecular basis of the high insecticidal potency of scorpion alpha-toxins

27 September 2017

1 reference

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The selectivity of scorpion alpha-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface

27 September 2017

1 reference

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Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

27 September 2017

1 reference

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A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels

27 September 2017

1 reference

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Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel

27 September 2017

1 reference

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Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Sodium channels and gating currents

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Site of covalent attachment of alpha-scorpion toxin derivatives in domain I of the sodium channel alpha subunit

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Localization of the receptor site for alpha-scorpion toxins by antibody mapping: implications for sodium channel topology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Binding of scorpion toxin to receptor sites associated with sodium channels in frog muscle. Correlation of voltage-dependent binding with activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Membrane potential-dependent binding of scorpion toxin to the action potential Na+ ionophore. Studies with a toxin derivative prepared by lactoperoxidase-catalyzed iodination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Closing in on the resting state of the Shaker K(+) channel.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Identification of structural elements of a scorpion alpha-neurotoxin important for receptor site recognition.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Sites and molecular mechanisms of modulation of Na(v)1.2 channels by Fyn tyrosine kinase.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Protein-protein docking with backbone flexibility.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

The unique pharmacology of the scorpion alpha-like toxin Lqh3 is associated with its flexible C-tail.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Combinatorial interaction of scorpion toxins Lqh-2, Lqh-3, and LqhalphaIT with sodium channel receptor sites-3.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider delta-atracotoxin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174582

Structural parts involved in activation and inactivation of the sodium channel

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21876146

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/21876146

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of an intracellular peptide segment involved in sodium channel inactivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21876146

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1112320108

1 reference

ADS bibcode

2011PNAS..10815426W

0 references

1 reference

1 reference

1 reference