CYP2C9*8 is prevalent among African-Americans: implications for pharmacogenetic dosing (Q24641999)

3

object named as

Steven A Lubitz

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Robert J. Desnick

6

object named as

Robert J Desnick

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author name string

Stuart A Scott

1

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Malgorzata Jaremko

2

0 references

Ruth Kornreich

CYP2C9 allelic variants: ethnic distribution and functional significance

4

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language of work or name

English

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publication date

August 2009

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published in

Pharmacogenomics

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volume

10

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issue

8

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page(s)

1243-55

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cites work

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Ethnic differences in warfarin maintenance dose requirement and its relationship with genetics

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Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement

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Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans

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27 September 2017

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Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations.

27 September 2017

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CYP4F2 genetic variant alters required warfarin dose

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A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9.

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Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose

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A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.

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Common VKORC1 and GGCX polymorphisms associated with warfarin dose

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Clinical consequences of cytochrome P450 2C9 polymorphisms

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CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population

27 September 2017

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Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans

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Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy

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Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements.

21 January 2018

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Genotypes of the cytochrome p450 isoform, CYP2C9, and the vitamin K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: a prospective study.

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Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans

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Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations

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Factors influencing warfarin dose requirements in African-Americans

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21 January 2018

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The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

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Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans

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Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivity

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Admixture and population stratification in African Caribbean populations

21 January 2018

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VKORCI haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation

28 November 2018

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Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.

28 November 2018

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The influence of sequence variations in factor VII, gamma-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement

28 November 2018

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12 December 2020

A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance

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12 December 2020

Warfarin Response and Vitamin K Epoxide Reductase Complex 1 in African Americans and Caucasians

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12 December 2020

Estimation of warfarin maintenance dose based on VKORC1 (-1639 G>A) and CYP2C9 genotypes

1 reference

12 December 2020

Warfarin pharmacogenetics

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12 December 2020