Brivaracetam: a rational drug discovery success story (Q24642768)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18552880%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Brivaracetam: a rational drug discovery success story (English)

1 reference

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9 January 2020

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1

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9 January 2020

author name string

M A Rogawski

series ordinal

1

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language of work or name

English

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publication date

16 June 2008

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British Journal of Pharmacology

9 January 2020

published in

1 reference

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9 January 2020

volume

154

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9 January 2020

issue

8

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9 January 2020

page(s)

1555-1557

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The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

9 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518467

Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518467

Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518467

Synaptic vesicle protein 2 enhances release probability at quiescent synapses

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518467

Localization and photoaffinity labelling of the levetiracetam binding site in rat brain and certain cell lines

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518467

Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518467

Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518467

ucb L059, a novel anti-convulsant drug: pharmacological profile in animals

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518467

Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518467

The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518467

Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18552880

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/BJP.2008.221

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18552880%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18552880%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

18552880

2 references