Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes (Q24642875)

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Molly E Moore

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Matthew B Soellner

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Pearl Tsang

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Carol A Caperelli

Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations

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language of work or name

English

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publication date

9 January 2007

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published in

Biochemistry

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volume

46

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issue

1

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page(s)

156-63

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cites work

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A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A

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Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution

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The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase

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De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementatio

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Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway

27 September 2017

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10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase

27 September 2017

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Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase

27 September 2017

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Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase

27 September 2017

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Substrate specificity of human glycinamide ribonucleotide transformylase

27 September 2017

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Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition

27 September 2017

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Combinatorial manipulation of three key active site residues in glycinamide ribonucleotide transformylase

27 September 2017

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Biochemical and mutational analysis of a plant virus polyprotein cleavage site

27 September 2017

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27 September 2017

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27 September 2017

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Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase

27 September 2017

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Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy

27 September 2017

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27 September 2017

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30 May 2018

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30 May 2018

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Heterologous expression and purification of active human phosphoribosylglycinamide formyltransferase as a single domain

30 May 2018

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A rapid screen of active site mutants in glycinamide ribonucleotide transformylase.

30 May 2018

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Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase.

30 May 2018

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30 May 2018

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Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway

28 November 2018

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10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

28 November 2018

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28 November 2018

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28 November 2018

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Evaluation of the kinetic mechanism of Escherichia coli glycinamide ribonucleotide transformylase

28 November 2018

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Identification and nucleotide sequence of a gene encoding 5'-phosphoribosylglycinamide transformylase in Escherichia coli K12.

28 November 2018

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Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthetic activities

28 November 2018

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