A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis (Q24644684)

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object named as

David Wheeler

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Norman J Haughey

Veera Venkata Ratnam Bandaru

5

object named as

Norman J Haughey

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2

object named as

Veera Venkata Ratnam Bandaru

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author name string

Avindra Nath

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis

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language of work or name

English

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publication date

November 2008

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published in

Brain

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volume

131

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issue

Pt 11

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page(s)

3092-102

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cites work

1 reference

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The extended family of neutral sphingomyelinases

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Corticospinal tract abnormalities are associated with weakness in multiple sclerosis

7 April 2017

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Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis

27 September 2017

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Dendritic cells are abundant in non-lesional gray matter in multiple sclerosis

27 September 2017

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Relapsing neuromyelitis optica and relapsing-remitting multiple sclerosis: differentiation at diffusion-tensor MR imaging of corpus callosum.

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Oral fingolimod (FTY720) for relapsing multiple sclerosis

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Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions

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Gas liquid chromatographic analysis of sphingosine bases in sphingolipids of human normal and multiple sclerosis cerebral white matter.

30 May 2018

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The CSF levels of total-tau and phosphotau in patients with relapsing-remitting multiple sclerosis.

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Local magnetization transfer ratio signal inhomogeneity is related to subsequent change in MTR in lesions and normal-appearing white-matter of multiple sclerosis patients.

21 January 2018

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Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment

21 January 2018

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Identification of autoantibodies associated with myelin damage in multiple sclerosis

21 January 2018

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Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia

21 January 2018

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Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells.

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Axonal injury in the cerebral normal-appearing white matter of patients with multiple sclerosis is related to concurrent demyelination in lesions but not to concurrent demyelination in normal-appearing white matter.

21 January 2018

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Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors.

21 January 2018

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Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis

21 January 2018

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High field MR imaging and 1H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis: correlation between metabolic alterations and diagnostic MR imaging criteria.

21 January 2018

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Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.

21 January 2018

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FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.

21 January 2018

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Role of lipid interactions in autoimmune demyelination

28 November 2018

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Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy

28 November 2018

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12 December 2020

Heightened intrathecal release of axonal cytoskeletal proteins in multiple sclerosis is associated with progressive disease and clinical disability

1 reference

12 December 2020

Analysis of sulfatide from rat cerebellum and multiple sclerosis white matter by negative ion electrospray mass spectrometry

1 reference

12 December 2020

Antibodies against light neurofilaments in multiple sclerosis patients

1 reference

12 December 2020

Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis

1 reference

12 December 2020

Low choline concentrations in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans

1 reference

12 December 2020

Increased generation of superoxide radicals in the blood of MS patients

1 reference

12 December 2020

Cortical demyelination in PML and MS: Similarities and differences

1 reference

12 December 2020

FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis

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12 December 2020

Identifiers

DOI

10.1093/BRAIN/AWN190

1 reference

3498597

3498597

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