BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells (Q24644700)

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Megan E Cavet

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Karl R VanderMeid

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Mercedes Salvador-Silva

4

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Francisco J López

5

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Keith W Ward

Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues

6

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language of work or name

English

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publication date

2009

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published in

Molecular Vision

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volume

15

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page(s)

2606-16

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cites work

1 reference

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Antiinflammatory action of glucocorticoids--new mechanisms for old drugs

7 April 2017

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Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation

7 April 2017

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Double-masked, placebo-controlled evaluation of loteprednol etabonate 0.5% for postoperative inflammation. Loteprednol Etabonate Post-operative Inflammation Study Group 1

7 April 2017

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

7 April 2017

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Mitogen-activated protein kinase pathways

7 April 2017

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Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases

7 April 2017

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Use of inhaled and oral corticosteroids and the long-term risk of cataract.

27 September 2017

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Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy

27 September 2017

1 reference

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Besifloxacin, a novel fluoroquinolone antimicrobial agent, exhibits potent inhibition of pro-inflammatory cytokines in human THP-1 monocytes

27 September 2017

1 reference

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Immunopathogenesis of ocular allergy: a schematic approach to different clinical entities

27 September 2017

1 reference

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Dexamethasone suppresses interleukin-1beta-induced human beta-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-kappaB transcriptional factor in A549 cells

27 September 2017

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27 September 2017

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27 September 2017

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Insight into the molecular mechanisms of glucocorticoid receptor action promotes identification of novel ligands with an improved therapeutic index.

27 September 2017

1 reference

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Diabetic retinopathy: the latest in current management

27 September 2017

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Intravitreal triamcinolone for refractory diabetic macular edema: two-year results of a double-masked, placebo-controlled, randomized clinical trial

27 September 2017

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PPARs and other nuclear receptors in inflammation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Corticosteroid effects on cell signalling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Ocular allergy: diagnosis and treatment

27 September 2017

1 reference

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Dissociated glucocorticoid receptor ligands: compounds with an improved therapeutic index.

27 September 2017

1 reference

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The search for safer glucocorticoid receptor ligands

27 September 2017

1 reference

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Inflammation suppressor genes: please switch out all the lights

27 September 2017

1 reference

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The glucocorticoid receptor as target for classic and novel anti-inflammatory therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.

27 September 2017

1 reference

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MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?

27 September 2017

1 reference

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Tissue differential microarray analysis of dexamethasone induction reveals potential mechanisms of steroid glaucoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

SEGRAs: a novel class of anti-inflammatory compounds.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

NFkappaB-dependent signaling pathways

27 September 2017

1 reference

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Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.

27 September 2017

1 reference

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Multiplexed particle-based flow cytometric assays

27 September 2017

1 reference

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Corticosteroids and glaucoma risk

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Perspectives in corticosteroid research.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Ocular Effects of Topical and Systemic Steroids

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Drugs to treat inflammation: a historical introduction

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Reduced myocilin expression in cultured monkey trabecular meshwork cells induced by a selective glucocorticoid receptor agonist: comparison with steroids

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Intravitreal triamcinolone for treatment of complicated proliferative diabetic retinopathy and proliferative vitreoretinopathy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Purification of astrocytes from adult human optic nerve heads by immunopanning

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

A global model to define the behavior of partial agonists (bell-shaped dose-response inducers) in pharmacological evaluation of activity in the presence of the full agonist.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790480

A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I

28 November 2018

1 reference

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Anti-inflammatory actions of glucocorticoids: molecular mechanisms

1 reference

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Controlled evaluation of loteprednol etabonate and prednisolone acetate in the treatment of acute anterior uveitis. Loteprednol Etabonate US Uveitis Study Group

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Localization of myocilin/trabecular meshwork--inducible glucocorticoid response protein in the human eye

1 reference

12 December 2020

Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization

1 reference

12 December 2020

Comparison of serum NO, TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus

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Corticosteroid-induced ocular hypertension and glaucoma: a brief review and update of the literature

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25 years of progress in the treatment of retinal diseases: where we have been, where we are now, and where we will be

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Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy

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Corticosteroids Reduce IL-6 in ASM Cells via Up-Regulation of MKP-1

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12 December 2020