Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain (Q24645468)

2

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Sharon R Grady

3

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Murali Gopalakrishnan

4

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Clark A Briggs

Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration

5

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language of work or name

English

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publication date

1 October 2009

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published in

Biochemical Pharmacology

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volume

78

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issue

7

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page(s)

795-802

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cites work

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ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders

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Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination

7 April 2017

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Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release

27 September 2017

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Roles of accessory subunits in alpha4beta2(*) nicotinic receptors

27 September 2017

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The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum

27 September 2017

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Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons

27 September 2017

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Heterologous expression of human {alpha}6{beta}4{beta}3{alpha}5 nicotinic acetylcholine receptors: binding properties consistent with their natural expression require quaternary subunit assembly including the {alpha}5 subunit

27 September 2017

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Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system

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Expression and functional characterisation of a human chimeric nicotinic receptor with alpha6beta4 properties

27 September 2017

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Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine.

27 September 2017

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The role of neuronal nicotinic acetylcholine receptor subunits in autonomic ganglia: lessons from knockout mice

27 September 2017

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Desensitization of neuronal nicotinic receptors

27 September 2017

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Study of the calcium dynamics of the human alpha4beta2, alpha3beta4 and alpha1beta1gammadelta nicotinic acetylcholine receptors

27 September 2017

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Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum

27 September 2017

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Extraneuronal cholinergic system in lymphocytes

27 September 2017

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ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys.

27 September 2017

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ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties.

27 September 2017

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Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors

27 September 2017

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Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors

27 September 2017

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Human alpha4beta2 acetylcholine receptors formed from linked subunits.

30 May 2018

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Partial deletion of the nicotinic cholinergic receptor alpha 4 or beta 2 subunit genes changes the acetylcholine sensitivity of receptor-mediated 86Rb+ efflux in cortex and thalamus and alters relative expression of alpha 4 and beta 2 subunits

30 May 2018

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Nicotinic alpha5 subunit deletion locally reduces high-affinity agonist activation without altering nicotinic receptor numbers

28 November 2018

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Pharmacology of alpha-conotoxin MII-sensitive subtypes of nicotinic acetylcholine receptors isolated by breeding of null mutant mice.

28 November 2018

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Deletion of the alpha7, beta2, or beta4 nicotinic receptor subunit genes identifies highly expressed subtypes with relatively low affinity for [3H]epibatidine

28 November 2018

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Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.

28 November 2018

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Comparative distribution of nicotinic receptor subtypes during development, adulthood and aging: an autoradiographic study in the rat brain

28 November 2018

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Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes.

28 November 2018

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Human alpha6 AChR subtypes: subunit composition, assembly, and pharmacological responses.

28 November 2018

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Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit

28 November 2018

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Four pharmacologically distinct subtypes of alpha4beta2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes.

28 November 2018

1 reference

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Desensitization of nicotine-stimulated 86Rb+ efflux from mouse brain synaptosomes

28 November 2018

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12 December 2020

Nicotinic agonists differ in activation and desensitization of 86Rb+ efflux from mouse thalamic synaptosomes

1 reference

12 December 2020

Neuronal nicotinic receptor expression in sensory neurons of the rat trigeminal ganglion: demonstration of alpha3beta4, a novel subtype in the mammalian nervous system

1 reference

12 December 2020

Heterogeneity of nicotinic cholinergic receptors in rat superior cervical and nodose Ganglia

1 reference

12 December 2020