Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow (Q24645717)

2

0 references

Shi Chen

3

0 references

Yuan Zhu

4

0 references

Jin Yuan

5

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Xiaohong Li

6

0 references

Xianlin Yang

7

0 references

Scott Knowles

8

0 references

Whitney Horn

9

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Yan Li

10

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Shaobo Zhang

11

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Yanzhu Yang

12

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Saeed T Vakili

13

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Menggang Yu

14

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Dennis Burns

15

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Kent Robertson

16

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Gary Hutchins

17

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Luis F Parada

18

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D Wade Clapp

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells

19

0 references

language of work or name

English

0 references

publication date

31 October 2008

0 references

published in

Cell

0 references

volume

135

0 references

issue

3

0 references

page(s)

437-48

0 references

cites work

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Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

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The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus

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Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling

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Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

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TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

7 April 2017

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Making progress through molecular attacks on cancer

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Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells

27 September 2017

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MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

27 September 2017

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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

27 September 2017

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Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression

27 September 2017

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'Green mice' as a source of ubiquitous green cells.

27 September 2017

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CSF-1 and its receptor in ovarian, endometrial and breast cancer

27 September 2017

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Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.

27 September 2017

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Role for the stem cell factor/KIT complex in Schwann cell neoplasia and mast cell proliferation associated with neurofibromatosis

27 September 2017

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27 September 2017

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Differential regulation of rasGAP and neurofibromatosis gene product activities

30 May 2018

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Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1.

30 May 2018

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Loss of FancC function results in decreased hematopoietic stem cell repopulating ability.

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Ultrastructural study of two patients with both piebaldism and neurofibromatosis 1

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Possible involvement of c-kit receptor and its ligand in increase of mast cells in neurofibroma tissues

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Neurofibromatosis 1 and piebaldism: a case report

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Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system

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10.1016/J.CELL.2008.08.041

Identifiers

DOI

1 reference

1340010

1340010

1 reference

1 reference

1 reference