Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin (Q24646364)

2

object named as

Susan W Sunnarborg

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author name string

Mark D Sternlicht

1

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Hosein Kouros-Mehr

3

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Ying Yu

4

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David C Lee

ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands

5

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language of work or name

English

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publication date

September 2005

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published in

Development

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volume

132

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page(s)

3923-33

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issue

17

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cites work

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TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

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Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

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Stromal effects on mammary gland development and breast cancer

7 April 2017

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ADAMs: key components in EGFR signalling and development

7 April 2017

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Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

7 April 2017

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TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation

7 April 2017

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7 April 2017

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Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

7 April 2017

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Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha

7 April 2017

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ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation

7 April 2017

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Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

7 April 2017

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Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

7 April 2017

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ErbB2 is required for ductal morphogenesis of the mammary gland

7 April 2017

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Increased expression of ADAM family members in human breast cancer and breast cancer cell lines

27 September 2017

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Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation

27 September 2017

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Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency

27 September 2017

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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

27 September 2017

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Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

27 September 2017

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Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells.

27 September 2017

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TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity.

27 September 2017

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Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis.

27 September 2017

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Effect of exogenous epidermal-like growth factors on mammary gland development and differentiation in the estrogen receptor-alpha knockout (ERKO) mouse.

27 September 2017

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Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality

27 September 2017

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Spotted long oligonucleotide arrays for human gene expression analysis.

27 September 2017

1 reference

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Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

27 September 2017

1 reference

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Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor α-converting Enzyme and Amphiregulin

27 September 2017

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27 September 2017

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Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide

27 September 2017

1 reference

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TACE is required for the activation of the EGFR by TGF-alpha in tumors

27 September 2017

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Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation

27 September 2017

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Tube or not tube: remodeling epithelial tissues by branching morphogenesis

27 September 2017

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Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.

27 September 2017

1 reference

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Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme

27 September 2017

1 reference

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Induction of ductal morphogenesis and lobular hyperplasia by amphiregulin in the mouse mammary gland.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Direct action of 17 beta-estradiol on mouse mammary ducts analyzed by sustained release implants and steroid autoradiography

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Ductal morphogenesis in the mouse mammary gland: evidence supporting a role for epidermal growth factor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Targeted disruption of ErbB2/Neu in the mammary epithelium results in impaired ductal outgrowth

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Clinical relevance of amphiregulin and VEGF in primary breast cancers

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

TACE is required for fetal murine cardiac development and modeling

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Persistent parity-induced changes in growth factors, TGF-beta3, and differentiation in the rodent mammary gland.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771180

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

28 November 2018

1 reference

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Strain-dependent epithelial defects in mice lacking the EGF receptor

28 November 2018

1 reference

12 December 2020

Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation

1 reference

12 December 2020

The epidermal growth factor receptor is not required for tumor necrosis factor-alpha action in normal mammary epithelial cells

1 reference

12 December 2020

An essential role for ectodomain shedding in mammalian development

1 reference

12 December 2020

Binding specificities and affinities of egf domains for ErbB receptors

1 reference

12 December 2020

Mammary gland specific hEGF receptor transgene expression induces neoplasia and inhibits differentiation

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12 December 2020

Functional significance of MMP-9 in tumor necrosis factor-induced proliferation and branching morphogenesis of mammary epithelial cells

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12 December 2020

Co-expression of epidermal growth factor receptor and transforming growth factor-alpha predicts worse prognosis in breast-cancer patients

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12 December 2020

Identifiers

DOI

10.1242/DEV.01966

1 reference

425172

425172

1 reference

1 reference

1 reference