The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function (Q24647179)

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P Schilcher

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L Zeitlmann

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W Kolanus

Molecular Biology of the Cell

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language of work or name

English

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publication date

August 1998

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published in

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volume

9

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issue

8

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page(s)

1981-94

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cites work

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Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

7 April 2017

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Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain

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Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function

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Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

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Structure of the binding site for inositol phosphates in a PH domain

7 April 2017

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Protein modules and signalling networks

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Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule

7 April 2017

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Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1

7 April 2017

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

7 April 2017

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7 April 2017

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The PH domain: a common piece in the structural patchwork of signalling proteins

7 April 2017

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The association of the C-terminal region of beta I sigma II spectrin to brain membranes is mediated by a PH domain, does not require membrane proteins, and coincides with a inositol-1,4,5 triphosphate binding site

7 April 2017

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N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

7 April 2017

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Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.

7 April 2017

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Membrane binding and enzymatic activation of a Dbl homology domain require the neighboring pleckstrin homology domain

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The pleckstrin homology domain of human beta I sigma II spectrin is targeted to the plasma membrane in vivo

27 September 2017

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27 September 2017

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Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin

27 September 2017

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PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

27 September 2017

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Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

27 September 2017

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N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization

27 September 2017

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Structural Characterization of the Interaction between a Pleckstrin Homology Domain and Phosphatidylinositol 4,5-Bisphosphate

27 September 2017

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Myristoylation is Required for the Intracellular Localization and Endocytic Function of ARF6

27 September 2017

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Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

27 September 2017

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A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

27 September 2017

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Recognition by Elam-1 of the Sialyl-Le x Determinant on Myeloid and Tumor Cells

27 September 2017

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PI3K: downstream AKTion blocks apoptosis

27 September 2017

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25450

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

30 May 2018

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Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

30 May 2018

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Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25450

The pleckstrin homology domain of phospholipase C-delta 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25450

Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange

28 November 2018

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12 December 2020

Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding

1 reference

12 December 2020

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1 reference

12 December 2020

Membrane association of Rac is required for high activity of the respiratory burst oxidase

1 reference

12 December 2020

Post-translational processing of Schizosaccharomyces pombe YPT proteins

1 reference

12 December 2020

A polybasic domain allows nonprenylated Ras proteins to function in Saccharomyces cerevisiae

1 reference

12 December 2020

Amino-terminal palmitate or polybasic domain can provide required second signal to myristate for membrane binding of p56lck

1 reference

12 December 2020

Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity

1 reference

12 December 2020

High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphate

1 reference

12 December 2020

Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid

1 reference

12 December 2020

The Association of the C-Terminal Region of β1ΣII Spectrin to Brain Membranes Is Mediated by a pH Domain, Does Not Require Membrane Proteins, and Coincides with a Inositol-1,4,5 Trisphosphate Binding Site

1 reference

Crossref

https://api.crossref.org/works/10.1091%2FMBC.9.8.1981

7 January 2021