Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site (Q24648048)

1

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Elizabeta Nemeth

2

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Julia B Goodnough

3

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Dharma R Thapa

4

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Victoria Gabayan

5

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language of work or name

English

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publication date

2008

1 reference

Blood Cells, Molecules and Diseases

published in

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volume

40

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page(s)

122-31

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issue

1

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cites work

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Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

7 April 2017

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7 April 2017

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7 April 2017

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Complex biosynthesis of the muscle-enriched iron regulator RGMc

7 April 2017

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Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

7 April 2017

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Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

7 April 2017

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Therapeutic benefits from targeting of ADAM family members

7 April 2017

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Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system

7 April 2017

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Isolation and expression pattern of three mouse homologues of chick Rgm

7 April 2017

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Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

7 April 2017

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RGM is a repulsive guidance molecule for retinal axons

7 April 2017

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GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy

7 April 2017

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A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

7 April 2017

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Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin

7 April 2017

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Proprotein convertases: lessons from knockouts

28 September 2017

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Regulation of iron acquisition and iron distribution in mammals

28 September 2017

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Emerging roles for ectodomain shedding in the regulation of inflammatory responses

28 September 2017

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Modulatory effects of sCD14 and LBP on LPS-host cell interactions

28 September 2017

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Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

28 September 2017

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Shedding light on ADAM metalloproteinases

28 September 2017

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28 September 2017

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The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes

28 September 2017

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The shed ectodomain of type XIII collagen affects cell behaviour in a matrix-dependent manner

28 September 2017

1 reference

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Curbing activation: proprotein convertases in homeostasis and pathology

28 September 2017

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Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability

28 September 2017

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1,10-Phenanthroline inhibits glycosylphosphatidylinositol anchoring by preventing phosphoethanolamine addition to glycosylphosphatidylinositol anchor precursors

28 September 2017

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28 September 2017

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Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation

28 September 2017

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BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211380

Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211380

Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211380

Membrane protein secretases

28 September 2017

1 reference

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Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation

28 September 2017

1 reference

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Soluble lipopolysaccharide receptor (CD14) is released via two different mechanisms from human monocytes and CD14 transfectants.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211380

Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211380

Factors affecting the ability of glycosylphosphatidylinositol-specific phospholipase D to degrade the membrane anchors of cell surface proteins

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211380

Limited redundancy of the proprotein convertase furin in mouse liver

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211380

Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211380

Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211380

Alterations in membrane-associated CD14 expression and the simultaneous liberation of soluble CD14 fragment in adherent macrophages mediated by a leukocyte carboxyl/aspartate protease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211380

Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/17869549

12 December 2020

inferred from PubMed ID database lookup

Furin directly cleaves proMMP-2 in the trans-Golgi network resulting in a nonfunctioning proteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17869549

12 December 2020

inferred from PubMed ID database lookup

Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12

1 reference

https://pubmed.ncbi.nlm.nih.gov/17869549

12 December 2020