Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin (Q24651265)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin (English)

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15 January 2020

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1

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15 January 2020

Stephen C. West

series ordinal

3

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15 January 2020

author name string

Ivan Ahel

series ordinal

2

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15 January 2020

language of work or name

English

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publication date

3 October 2008

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Journal of Biological Chemistry

15 January 2020

published in

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15 January 2020

volume

283

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15 January 2020

issue

49

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15 January 2020

page(s)

33994-34001

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Eukaryotic DNA ligases: structural and functional insights

15 January 2020

cites work

1 reference

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Two DNA-binding and nick recognition modules in human DNA ligase III

7 April 2017

1 reference

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Actions of aprataxin in multiple DNA repair pathways

7 April 2017

1 reference

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The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662222

Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662222

The macro domain is an ADP-ribose binding module

7 April 2017

1 reference

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The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

7 April 2017

1 reference

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Aprataxin, a novel protein that protects against genotoxic stress

7 April 2017

1 reference

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Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein

7 April 2017

1 reference

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Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases

7 April 2017

1 reference

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XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

7 April 2017

1 reference

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Structure-based analysis of catalysis and substrate definition in the HIT protein family

7 April 2017

1 reference

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MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family

7 April 2017

1 reference

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Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase

7 April 2017

1 reference

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Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins

7 April 2017

1 reference

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The role of poly(ADP-ribose) in the DNA damage signaling network

7 April 2017

1 reference

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Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins

7 April 2017

1 reference

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Three-dimensional structure of galactose-1-phosphate uridylyltransferase from Escherichia coli at 1.8 A resolution

7 April 2017

1 reference

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Defective DNA repair and neurodegenerative disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662222

The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662222

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene

7 April 2017

1 reference

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The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662222

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue

7 April 2017

1 reference

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Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity

7 April 2017

1 reference

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Single-strand break repair and genetic disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662222

Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia

7 April 2017

1 reference

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DNA strand break repair and human genetic disease

28 September 2017

1 reference

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DNA single-strand break repair is impaired in aprataxin-related ataxia.

28 September 2017

1 reference

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A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

28 September 2017

1 reference

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A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment

28 September 2017

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DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III.

28 September 2017

1 reference

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XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

28 September 2017

1 reference

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The HIT protein family: a new family of proteins present in prokaryotes, yeast and mammals

28 September 2017

1 reference

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The novel human gene aprataxin is directly involved in DNA single-strand-break repair.

28 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M807124200

21 January 2018

Identifiers

DOI

10.1074/JBC.M807124200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

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15 January 2020

1 reference