The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase (Q24651484)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7542745%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

title

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase (English)

1 reference

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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

20 October 2019

main subject

1 reference

Phosphoinositide-3-kinase regulatory subunit 3

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Sebastian Pons

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7542745%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

author name string

T Asano

2

1 reference

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20 October 2019

E Glasheen

3

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20 October 2019

M Miralpeix

4

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20 October 2019

Y Zhang

5

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20 October 2019

T L Fisher

6

1 reference

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20 October 2019

M G Myers

7

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20 October 2019

X J Sun

8

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20 October 2019

M F White

9

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20 October 2019

language of work or name

English

0 references

publication date

1 August 1995

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Molecular and Cellular Biology

20 October 2019

published in

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20 October 2019

volume

15

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20 October 2019

page(s)

4453-4465

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20 October 2019

issue

8

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Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor

20 October 2019

cites work

1 reference

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Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

7 April 2017

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7 April 2017

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7 April 2017

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

7 April 2017

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

7 April 2017

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Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

7 April 2017

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The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexes

7 April 2017

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Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase

7 April 2017

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Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton

28 September 2017

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PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

28 September 2017

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PI 3-kinase: structural and functional analysis of intersubunit interactions

28 September 2017

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Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

28 September 2017

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Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells

28 September 2017

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Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling

28 September 2017

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The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

28 September 2017

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28 September 2017

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28 September 2017

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Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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T cell receptor-associated alpha-phosphatidylinositol 3-kinase becomes activated by T cell receptor cross-linking and requires pp56lck

28 September 2017

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Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

28 September 2017

1 reference

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Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.

28 September 2017

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Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.

28 September 2017

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Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system

28 September 2017

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IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

30 May 2018

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Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

30 May 2018

1 reference

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The insulin-like growth factor I system in the rat cerebellum: developmental regulation and role in neuronal survival and differentiation.

30 May 2018

1 reference

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Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

30 May 2018

1 reference

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Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects

30 May 2018

1 reference

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Expression and function of IRS-1 in insulin signal transmission.

30 May 2018

1 reference

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Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells

30 May 2018

1 reference

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Insulin stimulates the tyrosine phosphorylation of a 61-kilodalton protein in rat adipocytes.

30 May 2018

1 reference

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The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor.

30 May 2018

1 reference

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Effects of wortmannin on increased glucose transport by insulin and norepinephrine in primary culture of brown adipocytes.

28 November 2018

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Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene.

28 November 2018

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The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.

28 November 2018

1 reference

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

28 November 2018

1 reference

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Identification of dynamin, a novel mechanochemical enzyme that mediates interactions between microtubules

28 November 2018

1 reference

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Synthesis, purification, and characterization of the cytoplasmic domain of the human insulin receptor using a baculovirus expression system.

28 November 2018

1 reference

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A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230685

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase

28 November 2018

1 reference

12 December 2020

JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes

1 reference

12 December 2020

Characterization of an endogenous substrate of the insulin receptor in cultured cells

1 reference

12 December 2020

A manual sequencing method for identification of phosphorylated amino acids in phosphopeptides

1 reference

12 December 2020

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle

1 reference

12 December 2020

Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells

1 reference

12 December 2020

Growth hormone stimulates tyrosine phosphorylation of insulin receptor substrate-1

1 reference

12 December 2020

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

12 December 2020

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin

1 reference

12 December 2020

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase

1 reference

12 December 2020

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

1 reference

12 December 2020

Characterization of a 60-kilodalton substrate of the insulin receptor kinase

1 reference

12 December 2020

Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.15.8.4453

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7542745%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7542745%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

1 reference