The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis (Q24651870)

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Jamie Haywood

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Ann L Craddock

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Martin G Belinsky

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Gary D Kruh

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Paul A Dawson

Proceedings of the National Academy of Sciences of the United States of America

6

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language of work or name

English

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publication date

11 March 2008

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published in

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volume

105

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page(s)

3891-6

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issue

10

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cites work

OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia

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The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter

7 April 2017

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Functional Complementation between a Novel Mammalian Polygenic Transport Complex and an Evolutionarily Ancient Organic Solute Transporter, OSTα-OSTβ

7 April 2017

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Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

7 April 2017

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Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter

7 April 2017

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Protein-protein interactions and membrane localization of the human organic solute transporter

7 April 2017

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Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

7 April 2017

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The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

7 April 2017

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FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine

7 April 2017

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ERAD: the long road to destruction

7 April 2017

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The enzymes, regulation, and genetics of bile acid synthesis

7 April 2017

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Enterohepatic bile salt transporters in normal physiology and liver disease

7 April 2017

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

7 April 2017

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FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption

7 April 2017

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Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function

28 September 2017

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Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice

28 September 2017

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Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids

28 September 2017

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Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2.

28 September 2017

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Analysis of the in vivo functions of Mrp3.

28 September 2017

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Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

28 September 2017

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Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate

28 September 2017

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Characterization, cDNA cloning, and functional expression of mouse ileal sodium-dependent bile acid transporter

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268840

Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268840

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

28 November 2018

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Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268840

Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts

28 November 2018

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12 December 2020

Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia

1 reference

12 December 2020

The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface

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12 December 2020

In vitro absorption of bile salts by small intestine of rats and guinea pigs

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12 December 2020

Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis

1 reference

12 December 2020

ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)

1 reference

12 December 2020

Analysis of 3-sulfated and nonsulfated bile acids by one-step solvolysis and high performance liquid chromatography

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12 December 2020

Negative feedback regulation of the ileal bile acid transport system in rodents

1 reference

12 December 2020

Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0712328105

7 January 2021