Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate. (Q24652426)

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Investigating the Structural Plasticity of a Cytochrome P450: THREE-DIMENSIONAL STRUCTURES OF P450 EryK AND BINDING TO ITS PHYSIOLOGICAL SUBSTRATE

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English	Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.	scientific article	Investigating the Structural Plasticity of a Cytochrome P450: THREE-DIMENSIONAL STRUCTURES OF P450 EryK AND BINDING TO ITS PHYSIOLOGICAL SUBSTRATE

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3 February 2020

Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate (English)

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3 February 2020

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Carmelinda Savino

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3 February 2020

Adriana E. Miele

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3 February 2020

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3 February 2020

Beatrice Vallone

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3 February 2020

Giuliano Sciara

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Giuliano Sciara

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3 February 2020

Steven G Kendrew

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Steven G Kendrew

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3 February 2020

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Linda C Montemiglio

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3 February 2020

Per Jemth

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22 July 2009

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3 February 2020

Journal of Biological Chemistry

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3 February 2020

284

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3 February 2020

42

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3 February 2020

29170-29179

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3 February 2020

Improvement in protein functional site prediction by distinguishing structural and functional constraints on protein family evolution using computational design

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7 April 2017

Cytochromes P450: a success story

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7 April 2017

Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris

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7 April 2017

The catalytic pathway of cytochrome p450cam at atomic resolution

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7 April 2017

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

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7 April 2017

Structure of cytochrome P450eryF involved in erythromycin biosynthesis

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7 April 2017

High-resolution crystal structure of cytochrome P450cam

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7 April 2017

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7 April 2017

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

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7 April 2017

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7 April 2017

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7 April 2017

Incorporation of prior phase information strengthens maximum-likelihood structure refinement

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7 April 2017

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*

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7 April 2017

Substrate binding to cytochromes P450.

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28 September 2017

Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation

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28 September 2017

Cytochrome p450 and chemical toxicology

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28 September 2017

Cytochromes P450 and drug discovery

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28 September 2017

Structure and mechanism of the 6-deoxyerythronolide B synthase

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28 September 2017

The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

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28 September 2017

Structural aspects of ligand binding to and electron transfer in bacterial and fungal P450s

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28 September 2017

Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

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28 September 2017

Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis

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28 September 2017

Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK.

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28 September 2017

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30 May 2018

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30 May 2018

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of C-12 hydroxylase EryK from Saccharopolyspora erythraea.

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21 January 2018

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Modeling protein-substrate interactions in the heme domain of cytochrome P450(BM-3).

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Cytochrome P450 enzymes from the metabolically diverse bacterium Rhodopseudomonas palustris

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21 January 2018

An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.

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21 January 2018

Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.

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21 January 2018

Improved bioconversion of 15-fluoro-6-deoxyerythronolide B to 15-fluoro-erythromycin A by overexpression of the eryK Gene in Saccharopolyspora erythraea

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21 January 2018

A Translation-Function Approach for Heavy-Atom Location in Macromolecular Crystallography

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28 November 2018

Rapid kinetics of Na+ binding to thrombin

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Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4

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based on heuristic

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based on heuristic

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Conformational change of cytochrome P450 1A2 induced by sodium chloride

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12 December 2020

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Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.003590

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19625248%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

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3 February 2020

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3 February 2020

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