Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate. (Q24652426)

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Investigating the Structural Plasticity of a Cytochrome P450: THREE-DIMENSIONAL STRUCTURES OF P450 EryK AND BINDING TO ITS PHYSIOLOGICAL SUBSTRATE

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English	Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.	scientific article	Investigating the Structural Plasticity of a Cytochrome P450: THREE-DIMENSIONAL STRUCTURES OF P450 EryK AND BINDING TO ITS PHYSIOLOGICAL SUBSTRATE

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3 February 2020

Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate (English)

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Carmelinda Savino

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Adriana E. Miele

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Beatrice Vallone

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Giuliano Sciara

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Giuliano Sciara

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Steven G Kendrew

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Steven G Kendrew

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Linda C Montemiglio

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Per Jemth

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22 July 2009

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3 February 2020

Journal of Biological Chemistry

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284

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42

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29170-29179

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3 February 2020

Improvement in protein functional site prediction by distinguishing structural and functional constraints on protein family evolution using computational design

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Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

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7 April 2017

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7 April 2017

Substrate binding to cytochromes P450.

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28 September 2017

Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis

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28 September 2017

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28 September 2017

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An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.

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Improved bioconversion of 15-fluoro-6-deoxyerythronolide B to 15-fluoro-erythromycin A by overexpression of the eryK Gene in Saccharopolyspora erythraea

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Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4

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Identifiers

10.1074/JBC.M109.003590

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