Protein kinase C iota: human oncogene, prognostic marker and therapeutic target (Q24652905)

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

Europe PubMed Central

title

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target (English)

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author name string

Alan P Fields

series ordinal

1

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Roderick P Regala

series ordinal

2

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language of work or name

English

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publication date

June 2007

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published in

Pharmacological Research

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volume

55

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issue

6

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page(s)

487-97

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cites work

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Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway

7 April 2017

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Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

7 April 2017

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Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

7 April 2017

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The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor

7 April 2017

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MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling

7 April 2017

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

7 April 2017

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The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

7 April 2017

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The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation

7 April 2017

1 reference

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Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.

7 April 2017

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Epithelial-mesenchymal transitions in tumour progression

7 April 2017

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Control of T helper 2 cell function and allergic airway inflammation by PKCzeta

7 April 2017

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Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase

7 April 2017

1 reference

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Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins

7 April 2017

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Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms

7 April 2017

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MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion

7 April 2017

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Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray

7 April 2017

1 reference

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Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway

7 April 2017

1 reference

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Regulation of phospholipase D isoenzymes by transforming Ras and atypical protein kinase C-iota

7 April 2017

1 reference

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SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus

7 April 2017

1 reference

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ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation

7 April 2017

1 reference

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A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation

7 April 2017

1 reference

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Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation

7 April 2017

1 reference

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Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control

7 April 2017

1 reference

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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

7 April 2017

1 reference

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Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis

7 April 2017

1 reference

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Protein kinase C and lipid signaling for sustained cellular responses

7 April 2017

1 reference

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Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms

7 April 2017

1 reference

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Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

7 April 2017

1 reference

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Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta

7 April 2017

1 reference

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Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

7 April 2017

1 reference

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Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein

7 April 2017

1 reference

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The molecular heterogeneity of protein kinase C and its implications for cellular regulation

7 April 2017

1 reference

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Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

7 April 2017

1 reference

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Cell signaling and function organized by PB1 domain interactions.

7 April 2017

1 reference

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Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.

28 September 2017

1 reference

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A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells

28 September 2017

1 reference

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Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.

28 September 2017

1 reference

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Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells

28 September 2017

1 reference

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Gold complexes in the treatment of rheumatoid arthritis.

28 September 2017

1 reference

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Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway

28 September 2017

1 reference

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Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo

28 September 2017

1 reference

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Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement

28 September 2017

1 reference

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Regulation of cell survival by atypical protein kinase C isozymes.

28 September 2017

1 reference

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The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.

28 September 2017

1 reference

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Cell polarity: Par6, aPKC and cytoskeletal crosstalk

28 September 2017

1 reference

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Role of zeta PKC in B-cell signaling and function

28 September 2017

1 reference

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Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis

28 September 2017

1 reference

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Protein kinase C inhibitors as novel anticancer drugs

28 September 2017

1 reference

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Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.

28 September 2017

1 reference

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PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.

28 September 2017

1 reference

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Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head and neck, despite loss of heterozygosity at this locus

28 September 2017

1 reference

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

28 September 2017

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The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters

28 September 2017

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Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells

28 September 2017

1 reference

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A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

28 September 2017

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Implication of atypical protein kinase C isozymes lambda and zeta in Ras mediated reorganization of the actin cytoskeleton and cyclin D1-induction

28 September 2017

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Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase

28 September 2017

1 reference

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Effects of anti-rheumatic gold salts on NF-kappa B mobilization and tumour necrosis factor-alpha (TNF-alpha)-induced neutrophil-dependent cytotoxicity for human endothelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Molecular definition of a small amplification domain within 3q26 in tumors of cervix, ovary, and lung

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Aberrant crypt foci of the colon as precursors of adenoma and cancer

28 September 2017

1 reference

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Amplification of the genes BCHE and SLC2A2 in 40% of squamous cell carcinoma of the lung

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid.

28 September 2017

1 reference

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Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta

28 September 2017

1 reference

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A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells

28 September 2017

1 reference

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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

28 September 2017

1 reference

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The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction

28 September 2017

1 reference

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The protein kinase C family: heterogeneity and its implications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Phorbol ester treatment of U937 cells with altered protein kinase C content and distribution induces cell death rather than differentiation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Reversion of Ras- and phosphatidylcholine-hydrolyzing phospholipase C-mediated transformation of NIH 3T3 cells by a dominant interfering mutant of protein kinase C lambda is accompanied by the loss of constitutive nuclear mitogen-activated protein k

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Ciota-mediated attenuation of p38 MAP kinase signaling.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Protein Kinase C-λ Knockout in Embryonic Stem Cells and Adipocytes Impairs Insulin-Stimulated Glucose Transport

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Inhibition of TPA-induced NF-kappaB nuclear translocation and production of NO and PGE2 by the anti-rheumatic gold compounds

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

NF-kappaB/RelA transactivation is required for atypical protein kinase C iota-mediated cell survival.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2705893

Protein kinase C isoforms involved in the transcriptional activation of cyclin D1 by transforming Ha-Ras

28 November 2018

1 reference

12 December 2020

OPR, PC and AID: all in the PB1 family

1 reference

12 December 2020

Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer

1 reference

12 December 2020

Protein kinase C in disease: cancer

1 reference

12 December 2020

Overexpression of protein kinase C-zeta stimulates leukemic cell differentiation

1 reference

12 December 2020

Comparative genomic hybridization analysis detects frequent, often high-level, overrepresentation of DNA sequences at 3q, 5p, 7p, and 8q in human non-small cell lung carcinomas

1 reference

12 December 2020

Immunocytochemical markers in stage I lung cancer: relevance to prognosis

1 reference

12 December 2020

Expression of the atypical protein kinase C (aPKC) isoforms iota/lambda and zeta during mouse embryogenesis

1 reference

12 December 2020

A proenzyme of cyclic nucleotide-independent protein kinase and its activation by calcium-dependent neutral protease from rat liver

1 reference

12 December 2020

10.1016/J.PHRS.2007.04.015

Identifiers

DOI

1 reference

1 reference

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PubMed publication ID

17570678

1 reference