Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation (Q24653215)

William Douglas Figg, Sr.

2

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4

object named as

William D Figg

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author name string

Christina Therapontos

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Erin R Gardner

Proceedings of the National Academy of Sciences of the United States of America

3

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language of work or name

English

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publication date

26 May 2009

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published in

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volume

106

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issue

21

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page(s)

8573-8

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describes a project that uses

ImageJ

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2688998/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Thalidomide is an inhibitor of angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

Defects and Disabilities of Thalidomide Children

7 April 2017

1 reference

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Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning

7 April 2017

1 reference

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A series of normal stages in the development of the chick embryo

7 April 2017

2 references

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7 April 2017

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In vivo imaging of embryonic vascular development using transgenic zebrafish

28 November 2018

1 reference

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Hydrolyzed metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway

28 September 2017

1 reference

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Mono- and dihydroxylated metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity

28 September 2017

1 reference

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Thalidomide metabolism and hydrolysis: mechanisms and implications

28 September 2017

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Birth and death of cells in limb development: a mapping study.

28 September 2017

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Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells.

28 September 2017

1 reference

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Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells

28 September 2017

1 reference

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Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs

28 September 2017

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Antitumor effects of thalidomide analogs in human prostate cancer xenografts implanted in immunodeficient mice

28 September 2017

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Thalidomide: A review of approved and investigational uses

28 September 2017

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Mechanism of action in thalidomide teratogenesis

28 September 2017

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Hypothesis: thalidomide embryopathy-proposed mechanism of action

28 September 2017

1 reference

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A short history of thalidomide embryopathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

Recognition of thalidomide defects

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

Thalidomide resistance is based on the capacity of the glutathione-dependent antioxidant defense.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

New cases of thalidomide embryopathy in Brazil

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

Comparative molecular field analysis and comparative molecular similarity indices analysis of thalidomide analogues as angiogenesis inhibitors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

Antiangiogenic activity of N-substituted and tetrafluorinated thalidomide analogues

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

Why study human limb malformations?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

Smad7 misexpression during embryonic angiogenesis causes vascular dilation and malformations independently of vascular smooth muscle cell function.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

A developmental model for thalidomide defects.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688998

The thin prep rat aortic ring assay: a modified method for the characterization of angiogenesis in whole mounts

28 November 2018

1 reference

12 December 2020

1 reference

12 December 2020

Early changes in limb buds of chick embryos after thalidomide treatment

1 reference

12 December 2020

Inhibition of angiogenesis by thalidomide requires metabolic activation, which is species-dependent

1 reference

12 December 2020

Teratogenic effects of thalidomide and related substances

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0901505106

1 reference

1124942

ADS bibcode

2009PNAS..106.8573T

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1124942

1 reference

1 reference

1 reference