Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells (Q24654211)

1

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Mu-Sheng Zeng

2

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Ajay Yadav

3

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Li-Bing Song

4

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Bao-Hong Guo

5

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Goberdhan P Dimri

describes a project that uses

7

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language of work or name

English

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publication date

1 June 2007

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published in

Cancer Research

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volume

67

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issue

11

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page(s)

5083-9

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ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2386662/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins

1 reference

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Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

7 April 2017

1 reference

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

7 April 2017

1 reference

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Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

7 April 2017

1 reference

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

The Akt-mTOR tango and its relevance to cancer

28 September 2017

1 reference

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What has senescence got to do with cancer?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer

28 September 2017

1 reference

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Stem cells and cancer; the polycomb connection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins

28 September 2017

1 reference

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The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells

28 September 2017

1 reference

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The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression

28 September 2017

1 reference

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Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

The Akt pathway in human breast cancer: a tissue-array-based analysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386662

10.1158/0008-5472.CAN-06-4368

28 November 2018

Identifiers

DOI

1 reference

1 reference

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PubMed publication ID

17545584

1 reference