Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1 (Q24654657)

12

object named as

Judah Folkman

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In-Hyun Park

8

object named as

In-Hyun Park

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M William Lensch

7

object named as

M William Lensch

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author name string

Kwan-Hyuck Baek

1

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Alexander Zaslavsky

2

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Ryan C Lynch

3

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Carmella Britt

4

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Yoshiaki Okada

5

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Richard J Siarey

6

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Sam S Yoon

9

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Takashi Minami

10

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Julie R Korenberg

11

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William C Aird

14

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Zygmunt Galdzicki

15

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Sandra Ryeom

Disease-specific induced pluripotent stem cells

16

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language of work or name

English

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publication date

25 June 2009

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published in

Nature

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volume

459

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issue

7250

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page(s)

1126-30

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

7 April 2017

1 reference

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Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

VEGF selectively induces Down syndrome critical region 1 gene expression in endothelial cells: a mechanism for feedback regulation of angiogenesis?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Down syndrome candidate region 1,a downstream target of VEGF, participates in endothelial cell migration and angiogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

A chromosome 21 critical region does not cause specific Down syndrome phenotypes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Risks of leukaemia and solid tumours in individuals with Down's syndrome.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Diabetic retinopathy in Down's syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Single-copy transgenic mice with chosen-site integration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

The mapping of transgenes by fluorescence in situ hybridization on G-banded mouse chromosomes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

A mouse model for Down syndrome exhibits learning and behaviour deficits.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Down's syndrome: an atheroma-free model?

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Cancer incidence of persons with down syndrome in Finland: A population-based study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Immunosuppressive drugs and the risk of cancer after organ transplantation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724004

Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19458618

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19458618

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A lack of neuroblastoma in Down syndrome: a study from 11 European countries

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19458618

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE08062

1 reference

Dimensions Publication ID

1030270548

0 references

1 reference

1 reference

PubMed publication ID

19458618

1 reference