Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction (Q24656085)

2002 Medicinal Chemistry Division Award Address: Monoamine Transporters and Opioid Receptors. Targets for Addiction Therapy

Europe PubMed Central

title

Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction (English)

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Amy Hauck Newman

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Richard B. Rothman

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1

object named as

Richard B Rothman

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Michael H Baumann

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object named as

Michael H Baumann

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author name string

Thomas E Prisinzano

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3

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language of work or name

English

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publication date

1 January 2008

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published in

Biochemical Pharmacology

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volume

75

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page(s)

2-16

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issue

1

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cites work

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Vanoxerine National Institute on Drug Abuse

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Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin

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Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation

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Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents

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A tolerance study of single and multiple dosing of the selective dopamine uptake inhibitor GBR 12909 in healthy subjects

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Response requirements and unit dose modify the effects of GBR 12909 on cocaine-maintained behavior

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28 September 2017

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Novel 3alpha-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine.

28 September 2017

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Preclinical evaluation of pharmacotherapies for treatment of cocaine and opioid abuse using drug self-administration procedures

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A review of the effects of dopaminergic agents on humans, animals, and drug-seeking behavior, and its implications for medication development. Focus on GBR 12909.

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The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action

28 September 2017

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Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the rat

28 September 2017

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28 September 2017

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28 September 2017

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Preclinical evaluation of GBR12909 decanoate as a long-acting medication for methamphetamine dependence

28 September 2017

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3'- and 4'-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys.

30 May 2018

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Novel benztropine [3a-(diphenylmethoxy)tropane] analogs as probes for the dopamine transporter.

30 May 2018

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30 May 2018

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Chronic administration of the selective dopamine uptake inhibitor GBR 12,909, but not cocaine, produces marked decreases in dopamine transporter density.

30 May 2018

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Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine

30 May 2018

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Relationship between subjective effects of cocaine and dopamine transporter occupancy.

30 May 2018

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Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, a long-acting ester derivative of GBR 12909.

30 May 2018

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Differential reinforcing effects of cocaine and GBR-12909: biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system.

30 May 2018

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Pharmacological characterization of the novel discriminative stimulus effects of a low dose of cocaine.

30 May 2018

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Self-administration of GBR 12909 on a fixed ratio and progressive ratio schedule in rats.

30 May 2018

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Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors

30 May 2018

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Binding of [3H]cocaine in mouse brain: kinetics and saturability.

30 May 2018

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Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons

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28 November 2018

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28 November 2018

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28 November 2018

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Development and evaluation of high throughput functional assay methods for HERG potassium channel

28 November 2018

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Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys

28 November 2018

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28 November 2018

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Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity.

28 November 2018

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Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans.

28 November 2018

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28 November 2018

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RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter.

28 November 2018

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28 November 2018

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Effects of drug history on the acquisition of responding maintained by GBR 12909 in rhesus monkeys.

28 November 2018

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Effects of GBR 12909 and cocaine on cocaine-maintained behavior in rhesus monkeys.

28 November 2018

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28 November 2018

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GBR12909 attenuates cocaine-induced activation of mesolimbic dopamine neurons in the rat.

28 November 2018

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Effects of monoamine reuptake inhibitors on cocaine self-administration in rats.

28 November 2018

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Effects of GBR 12909, a selective dopamine uptake inhibitor, on motor activity and operant behavior in the rat.

28 November 2018

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Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labeling of the dopamine uptake complex

28 November 2018

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12 December 2020

inferred from PubMed ID database lookup

Highly Selective Chiral N-Substituted 3α-[Bis(4‘-fluorophenyl)methoxy]tropane Analogues for the Dopamine Transporter: Synthesis and Comparative Molecular Field Analysis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17897630

12 December 2020

inferred from PubMed ID database lookup

Dopamine re-uptake inhibitors show inconsistent effects on the in vivo release of dopamine as measured by intracerebral dialysis in the rat

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17897630

12 December 2020

inferred from PubMed ID database lookup

Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.BCP.2007.08.007

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.BCP.2007.08.007

1 reference

2471395

2471395

1 reference

1 reference

1 reference